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- W2021144019 abstract "In a drug reprofiling attempt, we explored novel neuroprotective properties of 4-azasteroids by synthesizing chemical affinity tags capturing adenine nucleotide translocator-1, as a potential target. Dutasteride inhibits the mitochondrial transition pore and induces an increase of autophagosomal structures in human cell lines. In vivo, a surprising reduction of the beta-amyloid plaque load in a model for cerebral amyloidosis appears to connect release of neurotoxic peptides, mitochondrial apoptosis and autophagy." @default.
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- W2021144019 date "2008-05-09" @default.
- W2021144019 modified "2023-10-18" @default.
- W2021144019 title "A Connection between the Mitochondrial Permeability Transition Pore, Autophagy, and Cerebral Amyloidogenesis" @default.
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- W2021144019 doi "https://doi.org/10.1021/pr700686x" @default.
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