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• W2021163340 abstract "Antistasin is a Factor Xa inhibitor that is present in the salivary glands of the Mexican leech Haementeria officinalis. The antistasin protein consists of 119 amino acids, of which residues 1–55 (domain I) are 56% similar to residues 56–110 (domain II). Of the nine C-terminal amino acids (residues 111–119; domain III), four are positively charged. The reactive site for Factor Xa is located in domain I. In this study we assessed the role of separate domains and of individual amino acids in the reactive site for the inhibition of Factor Xa. A series of mutants was constructed and expressed in Chinese hamster ovary (CHO) cells. In vitro chromogenic assays for Factor Xa show that domain I is sufficient for inhibition of Factor Xa. Domains II and III neither contain any intrinsic Factor Xa inhibitory activity, nor contribute to the activity of domain I. Furthermore, domain II does not become a Factor Xa inhibitor by partially adaptating its sequence towards that of the reactive site in domain I. Mutation of the cysteine at position 33 is not crucial for Factor Xa inhibition, suggesting a relatively rigid reactive site loop structure." @default.
• W2021163340 created "2016-06-24" @default.
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• W2021163340 date "1994-07-01" @default.
• W2021163340 modified "2023-09-25" @default.
• W2021163340 title "Mutational analysis of antistasin, an inhibitor of blood coagulation factor xa derived from the mexican leech Haementeria officinalis" @default.
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• W2021163340 doi "https://doi.org/10.1016/0049-3848(94)90138-4" @default.
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