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- W2021166811 abstract "Human T-lymphotrophic virus type-1 (HTLV-1) infects approximately 15 to 20 million people worldwide, with endemic areas in Japan, the Caribbean, and Africa. The virus is spread through contact with bodily fluids containing infected cells, most often from mother to child through breast milk or via blood transfusion. After prolonged latency periods, approximately 3 to 5% of HTLV-1 infected individuals will develop either adult T-cell leukemia/lymphoma (ATL), or other lymphocyte-mediated disorders such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The genome of this complex retrovirus contains typical gag, pol, and env genes, but also unique nonstructural proteins encoded from the pX region. These nonstructural genes encode the Tax and Rex regulatory proteins, as well as novel proteins essential for viral spread in vivo such as, p30, p12, p13 and the antisense encoded HBZ. While progress has been made in the understanding of viral determinants of cell transformation and host immune responses, host and viral determinants of HTLV-1 transmission and spread during the early phases of infection are unclear. Improvements in the molecular tools to test these viral determinants in cellular and animal models have provided new insights into the early events of HTLV-1 infection. This review will focus on studies that test HTLV-1 determinants in context to full length infectious clones of the virus providing insights into the mechanisms of transmission and spread of HTLV-1." @default.
- W2021166811 created "2016-06-24" @default.
- W2021166811 creator A5019998970 @default.
- W2021166811 creator A5041904318 @default.
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- W2021166811 creator A5068289010 @default.
- W2021166811 creator A5078184468 @default.
- W2021166811 creator A5091434372 @default.
- W2021166811 date "2011-07-12" @default.
- W2021166811 modified "2023-09-25" @default.
- W2021166811 title "Molecular Determinants of Human T-lymphotropic Virus Type 1 Transmission and Spread" @default.
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