Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021168049> ?p ?o ?g. }
- W2021168049 endingPage "289" @default.
- W2021168049 startingPage "283" @default.
- W2021168049 abstract "Novel antimalarial agents are in demand due to the emergence of multidrug resistant strains. Ginseng, a medicinal plant with antiparasitic activity, contains components that can be used to treat the tropical disease malaria.Ginsenosides and polysaccharides are active components of ginseng. This study aimed to elucidate the ability of these compounds to inhibit the replication of Plasmodium yoelii in an attempt to determine whether the medicinal uses of ginseng are supported by pharmacological effects. New antimalarial compounds may be developed from ginsenosides and water-soluble ginseng polysaccharides (WGP).Ginsenosides and ginseng polysaccharides were prepared from ginseng. Antimalarial activities were examined by 4-day tests and repository tests. Macrophage phagocytosis was tested in normal and malaria-bearing mice.Ginseng polysaccharides could inhibit residual malaria infection. After a 6-day treatment, the parasitemia reductions of WGP and acidic ginseng polysaccharide (WGPA) were 55.66% and 64.73% at 200 mg/kg/day, respectively. Ginsenosides showed significant antimalarial activity on early infection. Protopanaxadiol-type ginsenosides caused 70.97% chemosuppression at 50 mg/kg/day, higher than 52.8% of total ginsenosides at the same dose.Protopanaxadiol-type ginsenosides have remarkably suppressive activity during early infection, while acidic ginseng polysaccharides have significant prophylactic activity against malaria by stimulating the immune system. We propose that the activity of ginsenosides is dependent upon non-specific carbohydrate interactions and that the activity of ginseng polysaccharides is due to immunological modulation. Ginsenosides and ginseng polysaccharides might have a potential application in antimalarial treatments." @default.
- W2021168049 created "2016-06-24" @default.
- W2021168049 creator A5001599800 @default.
- W2021168049 creator A5002864551 @default.
- W2021168049 creator A5005071062 @default.
- W2021168049 creator A5031276854 @default.
- W2021168049 creator A5033229269 @default.
- W2021168049 creator A5037458498 @default.
- W2021168049 creator A5045070821 @default.
- W2021168049 creator A5090657386 @default.
- W2021168049 date "2011-02-16" @default.
- W2021168049 modified "2023-10-01" @default.
- W2021168049 title "<i>In vivo</i>antimalarial activity of ginseng extracts" @default.
- W2021168049 cites W1545121368 @default.
- W2021168049 cites W1545486630 @default.
- W2021168049 cites W1585774085 @default.
- W2021168049 cites W1968834637 @default.
- W2021168049 cites W1972563819 @default.
- W2021168049 cites W1973739905 @default.
- W2021168049 cites W1979545488 @default.
- W2021168049 cites W1981747135 @default.
- W2021168049 cites W1983208188 @default.
- W2021168049 cites W1984883105 @default.
- W2021168049 cites W1990228074 @default.
- W2021168049 cites W1996703051 @default.
- W2021168049 cites W2001104014 @default.
- W2021168049 cites W2003208620 @default.
- W2021168049 cites W2004302141 @default.
- W2021168049 cites W2009855768 @default.
- W2021168049 cites W2022510326 @default.
- W2021168049 cites W2026169567 @default.
- W2021168049 cites W2028069148 @default.
- W2021168049 cites W2031528882 @default.
- W2021168049 cites W2033025082 @default.
- W2021168049 cites W2036664422 @default.
- W2021168049 cites W2038804284 @default.
- W2021168049 cites W2042079639 @default.
- W2021168049 cites W2045126465 @default.
- W2021168049 cites W2048596387 @default.
- W2021168049 cites W2048691731 @default.
- W2021168049 cites W2050687766 @default.
- W2021168049 cites W2064855181 @default.
- W2021168049 cites W2065091584 @default.
- W2021168049 cites W2067428749 @default.
- W2021168049 cites W2072029917 @default.
- W2021168049 cites W2075210096 @default.
- W2021168049 cites W2080701379 @default.
- W2021168049 cites W2080707579 @default.
- W2021168049 cites W2090155474 @default.
- W2021168049 cites W2096224929 @default.
- W2021168049 cites W2115073021 @default.
- W2021168049 cites W2127049281 @default.
- W2021168049 cites W2146000793 @default.
- W2021168049 cites W2153002689 @default.
- W2021168049 cites W2162934366 @default.
- W2021168049 cites W2315758134 @default.
- W2021168049 cites W2443045943 @default.
- W2021168049 cites W4231557749 @default.
- W2021168049 cites W4244717624 @default.
- W2021168049 cites W4378637684 @default.
- W2021168049 doi "https://doi.org/10.3109/13880209.2010.511235" @default.
- W2021168049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21323481" @default.
- W2021168049 hasPublicationYear "2011" @default.
- W2021168049 type Work @default.
- W2021168049 sameAs 2021168049 @default.
- W2021168049 citedByCount "17" @default.
- W2021168049 countsByYear W20211680492012 @default.
- W2021168049 countsByYear W20211680492013 @default.
- W2021168049 countsByYear W20211680492014 @default.
- W2021168049 countsByYear W20211680492016 @default.
- W2021168049 countsByYear W20211680492017 @default.
- W2021168049 countsByYear W20211680492018 @default.
- W2021168049 countsByYear W20211680492019 @default.
- W2021168049 countsByYear W20211680492020 @default.
- W2021168049 countsByYear W20211680492021 @default.
- W2021168049 countsByYear W20211680492022 @default.
- W2021168049 crossrefType "journal-article" @default.
- W2021168049 hasAuthorship W2021168049A5001599800 @default.
- W2021168049 hasAuthorship W2021168049A5002864551 @default.
- W2021168049 hasAuthorship W2021168049A5005071062 @default.
- W2021168049 hasAuthorship W2021168049A5031276854 @default.
- W2021168049 hasAuthorship W2021168049A5033229269 @default.
- W2021168049 hasAuthorship W2021168049A5037458498 @default.
- W2021168049 hasAuthorship W2021168049A5045070821 @default.
- W2021168049 hasAuthorship W2021168049A5090657386 @default.
- W2021168049 hasBestOaLocation W20211680491 @default.
- W2021168049 hasConcept C100817775 @default.
- W2021168049 hasConcept C142724271 @default.
- W2021168049 hasConcept C185592680 @default.
- W2021168049 hasConcept C203014093 @default.
- W2021168049 hasConcept C204787440 @default.
- W2021168049 hasConcept C2775867548 @default.
- W2021168049 hasConcept C2776486806 @default.
- W2021168049 hasConcept C2776539398 @default.
- W2021168049 hasConcept C2777032962 @default.
- W2021168049 hasConcept C2778048844 @default.
- W2021168049 hasConcept C2778371730 @default.
- W2021168049 hasConcept C2778564307 @default.