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- W2021170620 abstract "Since the discovery of sildenafil in 1989 as a highly selective inhibitor of the phosphodiesterase type-5 (PDE-5) receptor, 2 additional PDE-5 inhibitors, tadalafil and vardenafil, have emerged as safe and effective treatments of erectile dysfunction (ED). Enzymes in the PDE family catalyze the hydrolysis of the intracellular signaling molecules cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which is the second messenger of nitric oxide (NO) and a principal mediator of smooth muscle relaxation and vasodilation. Sildenafil was initially introduced for clinical use as the result of extensive research on chemical agents targeting PDE-5 that might potentially be useful in the treatment of coronary heart disease. Erection is largely a hemodynamic event, which is regulated by vascular tone and blood flow balance in the penis. Endothelial dysfunction, an early component of atherosclerosis, may inhibit a vascular event such as erection and is rarely confined to the arteries supplying blood to the penis, but more likely occurs throughout the vascular bed. In addition to the effects of the NO-cGMP signaling pathway on cavernosal smooth muscle, clinical findings have suggested that vascular tone in the pulmonary, coronary, and other vascular tissues expressed by PDE-5 is also influenced by this signal transduction mechanism. This has led to the emergence of novel therapeutic indications for sildenafil over a range of cardiovascular conditions that are either well-established risk factors or comorbidities with ED. Recently, the U.S. Food and Drug Administration approved sildenafil as an orally active therapy for the treatment of primary pulmonary hypertension. The drug will be marketed under the trade name of Revatio, not Viagra, the name used for the ED indication. The approved dose for primary pulmonary hypertension is 20 mg 3 times daily." @default.
- W2021170620 created "2016-06-24" @default.
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- W2021170620 date "2007-03-01" @default.
- W2021170620 modified "2023-10-16" @default.
- W2021170620 title "Type 5 Phosphodiesterase Inhibitors in the Treatment of Erectile Dysfunction and Cardiovascular Disease" @default.
- W2021170620 cites W1548435756 @default.
- W2021170620 cites W1838828609 @default.
- W2021170620 cites W1966415714 @default.
- W2021170620 cites W1967851670 @default.
- W2021170620 cites W1968693538 @default.
- W2021170620 cites W1972634087 @default.
- W2021170620 cites W1975319833 @default.
- W2021170620 cites W1976883422 @default.
- W2021170620 cites W1977354362 @default.
- W2021170620 cites W1980991785 @default.
- W2021170620 cites W1982601738 @default.
- W2021170620 cites W1982642084 @default.
- W2021170620 cites W1989792368 @default.
- W2021170620 cites W1990323222 @default.
- W2021170620 cites W1990467189 @default.
- W2021170620 cites W1990800322 @default.
- W2021170620 cites W1995725983 @default.
- W2021170620 cites W1995896668 @default.
- W2021170620 cites W1996209758 @default.
- W2021170620 cites W1998143238 @default.
- W2021170620 cites W2003014193 @default.
- W2021170620 cites W2003140298 @default.
- W2021170620 cites W2003302900 @default.
- W2021170620 cites W2006654512 @default.
- W2021170620 cites W2008949374 @default.
- W2021170620 cites W2010124072 @default.
- W2021170620 cites W2012177749 @default.
- W2021170620 cites W2012365138 @default.
- W2021170620 cites W2014711248 @default.
- W2021170620 cites W2016408307 @default.
- W2021170620 cites W2021965311 @default.
- W2021170620 cites W2024649391 @default.
- W2021170620 cites W2025129645 @default.
- W2021170620 cites W2027227731 @default.
- W2021170620 cites W2031733455 @default.
- W2021170620 cites W2042239656 @default.
- W2021170620 cites W2045150258 @default.
- W2021170620 cites W2045719262 @default.
- W2021170620 cites W2045940958 @default.
- W2021170620 cites W2047184366 @default.
- W2021170620 cites W2054260665 @default.
- W2021170620 cites W2058096049 @default.
- W2021170620 cites W2061747153 @default.
- W2021170620 cites W2062075871 @default.
- W2021170620 cites W2062678616 @default.
- W2021170620 cites W2067078790 @default.
- W2021170620 cites W2068239827 @default.
- W2021170620 cites W2073482879 @default.
- W2021170620 cites W2074408964 @default.
- W2021170620 cites W2074646239 @default.
- W2021170620 cites W2088077779 @default.
- W2021170620 cites W2092061563 @default.
- W2021170620 cites W2092237225 @default.
- W2021170620 cites W2093015607 @default.
- W2021170620 cites W2095255029 @default.
- W2021170620 cites W2095820279 @default.
- W2021170620 cites W2099679633 @default.
- W2021170620 cites W2099984876 @default.
- W2021170620 cites W2102994334 @default.
- W2021170620 cites W2105089669 @default.
- W2021170620 cites W2105851379 @default.
- W2021170620 cites W2106356560 @default.
- W2021170620 cites W2111494287 @default.
- W2021170620 cites W2114534180 @default.
- W2021170620 cites W2118905420 @default.
- W2021170620 cites W2120560469 @default.
- W2021170620 cites W2121376498 @default.
- W2021170620 cites W2121462486 @default.
- W2021170620 cites W2121724790 @default.
- W2021170620 cites W2122750966 @default.
- W2021170620 cites W2123366678 @default.
- W2021170620 cites W2125142347 @default.
- W2021170620 cites W2127312355 @default.
- W2021170620 cites W2129476741 @default.
- W2021170620 cites W2132499295 @default.
- W2021170620 cites W2133844656 @default.
- W2021170620 cites W2139041982 @default.
- W2021170620 cites W2143661166 @default.
- W2021170620 cites W2146217294 @default.
- W2021170620 cites W2147232111 @default.
- W2021170620 cites W2150242032 @default.
- W2021170620 cites W2151730602 @default.
- W2021170620 cites W2158596999 @default.
- W2021170620 cites W2159214565 @default.
- W2021170620 cites W2159885935 @default.
- W2021170620 cites W2160314451 @default.
- W2021170620 cites W2163769469 @default.
- W2021170620 cites W2164474017 @default.