Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021180495> ?p ?o ?g. }
- W2021180495 endingPage "771" @default.
- W2021180495 startingPage "759" @default.
- W2021180495 abstract "Hsp27 belongs to the small heat shock protein family, which are ATP-independent chaperones. The most important function of Hsp27 is based on its ability to bind non-native proteins and inhibit the aggregation of incorrectly folded proteins maintaining them in a refolding-competent state. Additionally, it has anti-apoptotic and antioxidant activities. To study the effect of Hsp27 on memory and synaptic functions, amyloid-β (Aβ) accumulation, and neurodegeneration, we generated transgenic mice overexpressing human Hsp27 protein and crossed with APPswe/PS1dE9 mouse strain, a mouse model of Alzheimer's disease (AD). Using different behavioral tests, we found that spatial learning was impaired in AD model mice and was rescued by Hsp27 overexpression. Electrophysiological recordings have revealed that excitability of neurons was significantly increased, and long-term potentiation (LTP) was impaired in AD model mice, whereas they were normalized in Hsp27 overexpressing AD model mice. Using anti-amyloid antibody, we counted significantly less amyloid plaques in the brain of APPswe/PS1dE9/Hsp27 animals compared to AD model mice. These results suggest that overexpression of Hsp27 protein might ameliorate certain symptoms of AD." @default.
- W2021180495 created "2016-06-24" @default.
- W2021180495 creator A5000165011 @default.
- W2021180495 creator A5000951507 @default.
- W2021180495 creator A5001615751 @default.
- W2021180495 creator A5001757088 @default.
- W2021180495 creator A5008804674 @default.
- W2021180495 creator A5027511635 @default.
- W2021180495 creator A5040961070 @default.
- W2021180495 creator A5075165960 @default.
- W2021180495 creator A5077001798 @default.
- W2021180495 creator A5082940933 @default.
- W2021180495 creator A5084886058 @default.
- W2021180495 date "2013-04-21" @default.
- W2021180495 modified "2023-10-18" @default.
- W2021180495 title "Overexpression of Hsp27 ameliorates symptoms of Alzheimer's disease in APP/PS1 mice" @default.
- W2021180495 cites W1537274817 @default.
- W2021180495 cites W1560089066 @default.
- W2021180495 cites W1581409175 @default.
- W2021180495 cites W1584834830 @default.
- W2021180495 cites W1598830628 @default.
- W2021180495 cites W1964314802 @default.
- W2021180495 cites W1965792398 @default.
- W2021180495 cites W1966923623 @default.
- W2021180495 cites W1971200109 @default.
- W2021180495 cites W1980825524 @default.
- W2021180495 cites W1985268049 @default.
- W2021180495 cites W1986384924 @default.
- W2021180495 cites W1993220836 @default.
- W2021180495 cites W1994467653 @default.
- W2021180495 cites W2005031405 @default.
- W2021180495 cites W2009692250 @default.
- W2021180495 cites W2017429750 @default.
- W2021180495 cites W2027846974 @default.
- W2021180495 cites W2028125541 @default.
- W2021180495 cites W2030428515 @default.
- W2021180495 cites W2045865115 @default.
- W2021180495 cites W2047190839 @default.
- W2021180495 cites W2049438990 @default.
- W2021180495 cites W2049511526 @default.
- W2021180495 cites W2054686729 @default.
- W2021180495 cites W2055085279 @default.
- W2021180495 cites W2055883416 @default.
- W2021180495 cites W2072925339 @default.
- W2021180495 cites W2074637456 @default.
- W2021180495 cites W2076951524 @default.
- W2021180495 cites W2080274663 @default.
- W2021180495 cites W2083179056 @default.
- W2021180495 cites W2085054634 @default.
- W2021180495 cites W2096963202 @default.
- W2021180495 cites W2097127336 @default.
- W2021180495 cites W2097623950 @default.
- W2021180495 cites W2097680048 @default.
- W2021180495 cites W2100159830 @default.
- W2021180495 cites W2110252008 @default.
- W2021180495 cites W2116784956 @default.
- W2021180495 cites W2129678592 @default.
- W2021180495 cites W2133947651 @default.
- W2021180495 cites W2142943752 @default.
- W2021180495 cites W2145787481 @default.
- W2021180495 cites W2148026632 @default.
- W2021180495 cites W2156220037 @default.
- W2021180495 cites W2169308121 @default.
- W2021180495 cites W2171049750 @default.
- W2021180495 cites W2172343762 @default.
- W2021180495 cites W2203252197 @default.
- W2021180495 cites W22062734 @default.
- W2021180495 cites W56343202 @default.
- W2021180495 doi "https://doi.org/10.1007/s12192-013-0428-9" @default.
- W2021180495 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3789881" @default.
- W2021180495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23605646" @default.
- W2021180495 hasPublicationYear "2013" @default.
- W2021180495 type Work @default.
- W2021180495 sameAs 2021180495 @default.
- W2021180495 citedByCount "70" @default.
- W2021180495 countsByYear W20211804952013 @default.
- W2021180495 countsByYear W20211804952014 @default.
- W2021180495 countsByYear W20211804952015 @default.
- W2021180495 countsByYear W20211804952016 @default.
- W2021180495 countsByYear W20211804952017 @default.
- W2021180495 countsByYear W20211804952018 @default.
- W2021180495 countsByYear W20211804952019 @default.
- W2021180495 countsByYear W20211804952020 @default.
- W2021180495 countsByYear W20211804952021 @default.
- W2021180495 countsByYear W20211804952022 @default.
- W2021180495 countsByYear W20211804952023 @default.
- W2021180495 crossrefType "journal-article" @default.
- W2021180495 hasAuthorship W2021180495A5000165011 @default.
- W2021180495 hasAuthorship W2021180495A5000951507 @default.
- W2021180495 hasAuthorship W2021180495A5001615751 @default.
- W2021180495 hasAuthorship W2021180495A5001757088 @default.
- W2021180495 hasAuthorship W2021180495A5008804674 @default.
- W2021180495 hasAuthorship W2021180495A5027511635 @default.
- W2021180495 hasAuthorship W2021180495A5040961070 @default.
- W2021180495 hasAuthorship W2021180495A5075165960 @default.
- W2021180495 hasAuthorship W2021180495A5077001798 @default.
- W2021180495 hasAuthorship W2021180495A5082940933 @default.
- W2021180495 hasAuthorship W2021180495A5084886058 @default.