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• W2021190535 abstract "Cell cycle progression during oocyte maturation requires the strict temporal regulation of maternal mRNA translation. The intrinsic basis of this temporal control has not been fully elucidated but appears to involve distinct mRNA 3′ UTR regulatory elements. In this study, we identify a novel translational control sequence (TCS) that exerts repression of target mRNAs in immature oocytes of the frog, Xenopus laevis, and can direct early cytoplasmic polyadenylation and translational activation during oocyte maturation. The TCS is functionally distinct from the previously characterized Musashi/polyadenylation response element (PRE) and the cytoplasmic polyadenylation element (CPE). We report that TCS elements exert translational repression in both the Wee1 mRNA 3′ UTR and the pericentriolar material-1 (Pcm-1) mRNA 3′ UTR in immature oocytes. During oocyte maturation, TCS function directs the early translational activation of the Pcm-1 mRNA. By contrast, we demonstrate that CPE sequences flanking the TCS elements in the Wee1 3′ UTR suppress the ability of the TCS to direct early translational activation. Our results indicate that a functional hierarchy exists between these distinct 3′ UTR regulatory elements to control the timing of maternal mRNA translational activation during oocyte maturation." @default.
• W2021190535 created "2016-06-24" @default.
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• W2021190535 date "2008-05-01" @default.
• W2021190535 modified "2023-09-24" @default.
• W2021190535 title "A novel mRNA 3′ untranslated region translational control sequence regulates Xenopus Wee1 mRNA translation" @default.
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• W2021190535 doi "https://doi.org/10.1016/j.ydbio.2008.02.033" @default.
• W2021190535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2562724" @default.
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• W2021190535 hasPublicationYear "2008" @default.
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