Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021193712> ?p ?o ?g. }
- W2021193712 abstract "Abstract Glutamate transporters in the central nervous system remove glutamate released from neurons to terminate the signal. These transporters localize to astrocyte process tips approaching neuronal synapses. The mechanisms underlying the localization of glutamate transporters to these processes, however, are not known. In this study, we demonstrate that the trimeric transmembrane transporter domain fragment of glutamate transporters, lacking both N- and C-terminal cytoplasmic regions, localized to filopodia tips. This is a common property of trimeric transporters including a neutral amino acid transporter ASCT1. Astrocyte specific proteins are not required for the filopodia tip localization. An extracellular loop at the centre of the 4 th transmembrane helices, unique for metazoans, is required for the localization. Moreover, a C186S mutation at the 4 th transmembrane region of EAAT1, found in episodic ataxia patients, significantly decreased its process tip localization. The transmembrane transporter domain fragments of glutamate transporters also localized to astrocyte process tips in cultured hippocampal slice. These results indicate that the transmembrane transporter domain of glutamate transporters have an additional function as a sorting signal to process tips." @default.
- W2021193712 created "2016-06-24" @default.
- W2021193712 creator A5017362199 @default.
- W2021193712 creator A5053916125 @default.
- W2021193712 date "2015-03-12" @default.
- W2021193712 modified "2023-09-27" @default.
- W2021193712 title "The transmembrane transporter domain of glutamate transporters is a process tip localizer" @default.
- W2021193712 cites W1536896113 @default.
- W2021193712 cites W1550984095 @default.
- W2021193712 cites W1797368996 @default.
- W2021193712 cites W1842002473 @default.
- W2021193712 cites W1884333838 @default.
- W2021193712 cites W1964063168 @default.
- W2021193712 cites W1966556202 @default.
- W2021193712 cites W1971324155 @default.
- W2021193712 cites W1972340177 @default.
- W2021193712 cites W1981765517 @default.
- W2021193712 cites W1990978305 @default.
- W2021193712 cites W1993495907 @default.
- W2021193712 cites W1996796508 @default.
- W2021193712 cites W1999613366 @default.
- W2021193712 cites W2003410399 @default.
- W2021193712 cites W2005302642 @default.
- W2021193712 cites W2010307662 @default.
- W2021193712 cites W2013106583 @default.
- W2021193712 cites W2016575029 @default.
- W2021193712 cites W2028279469 @default.
- W2021193712 cites W2030352252 @default.
- W2021193712 cites W2031618550 @default.
- W2021193712 cites W2035891650 @default.
- W2021193712 cites W2041664907 @default.
- W2021193712 cites W2042141949 @default.
- W2021193712 cites W2055864348 @default.
- W2021193712 cites W2057376499 @default.
- W2021193712 cites W2065086461 @default.
- W2021193712 cites W2081927805 @default.
- W2021193712 cites W2082879602 @default.
- W2021193712 cites W2083848895 @default.
- W2021193712 cites W2084609127 @default.
- W2021193712 cites W2092939335 @default.
- W2021193712 cites W2095267065 @default.
- W2021193712 cites W2099540110 @default.
- W2021193712 cites W2104538689 @default.
- W2021193712 cites W2110863368 @default.
- W2021193712 cites W2120741241 @default.
- W2021193712 cites W2127443779 @default.
- W2021193712 cites W2136920852 @default.
- W2021193712 cites W2137015675 @default.
- W2021193712 cites W2140166756 @default.
- W2021193712 cites W2147869206 @default.
- W2021193712 cites W2152732725 @default.
- W2021193712 cites W2160644313 @default.
- W2021193712 cites W2168367599 @default.
- W2021193712 cites W4250794494 @default.
- W2021193712 doi "https://doi.org/10.1038/srep09032" @default.
- W2021193712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4357008" @default.
- W2021193712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25761899" @default.
- W2021193712 hasPublicationYear "2015" @default.
- W2021193712 type Work @default.
- W2021193712 sameAs 2021193712 @default.
- W2021193712 citedByCount "14" @default.
- W2021193712 countsByYear W20211937122016 @default.
- W2021193712 countsByYear W20211937122017 @default.
- W2021193712 countsByYear W20211937122018 @default.
- W2021193712 countsByYear W20211937122019 @default.
- W2021193712 countsByYear W20211937122021 @default.
- W2021193712 countsByYear W20211937122022 @default.
- W2021193712 countsByYear W20211937122023 @default.
- W2021193712 crossrefType "journal-article" @default.
- W2021193712 hasAuthorship W2021193712A5017362199 @default.
- W2021193712 hasAuthorship W2021193712A5053916125 @default.
- W2021193712 hasBestOaLocation W20211937121 @default.
- W2021193712 hasConcept C104317684 @default.
- W2021193712 hasConcept C113657865 @default.
- W2021193712 hasConcept C118892022 @default.
- W2021193712 hasConcept C12554922 @default.
- W2021193712 hasConcept C149011108 @default.
- W2021193712 hasConcept C156310829 @default.
- W2021193712 hasConcept C169760540 @default.
- W2021193712 hasConcept C170493617 @default.
- W2021193712 hasConcept C185592680 @default.
- W2021193712 hasConcept C24530287 @default.
- W2021193712 hasConcept C2777542381 @default.
- W2021193712 hasConcept C515207424 @default.
- W2021193712 hasConcept C529278444 @default.
- W2021193712 hasConcept C55493867 @default.
- W2021193712 hasConcept C57581600 @default.
- W2021193712 hasConcept C61174792 @default.
- W2021193712 hasConcept C86803240 @default.
- W2021193712 hasConcept C95444343 @default.
- W2021193712 hasConceptScore W2021193712C104317684 @default.
- W2021193712 hasConceptScore W2021193712C113657865 @default.
- W2021193712 hasConceptScore W2021193712C118892022 @default.
- W2021193712 hasConceptScore W2021193712C12554922 @default.
- W2021193712 hasConceptScore W2021193712C149011108 @default.
- W2021193712 hasConceptScore W2021193712C156310829 @default.
- W2021193712 hasConceptScore W2021193712C169760540 @default.
- W2021193712 hasConceptScore W2021193712C170493617 @default.
- W2021193712 hasConceptScore W2021193712C185592680 @default.
- W2021193712 hasConceptScore W2021193712C24530287 @default.