Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021194016> ?p ?o ?g. }
- W2021194016 endingPage "510" @default.
- W2021194016 startingPage "501" @default.
- W2021194016 abstract "Gastric acid secretion is mediated by the H/K-ATPase of parietal cells. Activation of acid secretion involves insertion of H/K-ATPase into the parietal cell plasmalemma, while its cessation is associated with reinternalization of the H/K-ATPase into an intracellular storage compartment. The cytoplasmic tail of the H/K-ATPase β subunit includes a four residue sequence homologous to tyrosine-based endocytosis signals. We generated transgenic mice expressing H/K- ATPase β subunit in which this motif's tyrosine residue is mutated to alanine. Gastric glands from animals expressing mutant β subunit constitutively secrete acid and continuously express H/K-ATPase at their cell surfaces. Thus, the β subunit's tyrosine-based signal is required for the internalization of H/K-ATPase and for the termination of acid secretion. As a consequence of chronic hyperacidity, the mice develop gastric ulcers and a hypertrophic gastropathy resembling Menetrier's disease." @default.
- W2021194016 created "2016-06-24" @default.
- W2021194016 creator A5004067673 @default.
- W2021194016 creator A5029740494 @default.
- W2021194016 creator A5031384028 @default.
- W2021194016 creator A5041557565 @default.
- W2021194016 creator A5065040724 @default.
- W2021194016 creator A5076423900 @default.
- W2021194016 creator A5082597667 @default.
- W2021194016 date "1997-08-01" @default.
- W2021194016 modified "2023-09-26" @default.
- W2021194016 title "A Tyrosine-Based Signal Targets H/K-ATPase to a Regulated Compartment and Is Required for the Cessation of Gastric Acid Secretion" @default.
- W2021194016 cites W1561069887 @default.
- W2021194016 cites W1569800624 @default.
- W2021194016 cites W1591841346 @default.
- W2021194016 cites W1647423442 @default.
- W2021194016 cites W1678223592 @default.
- W2021194016 cites W1742521269 @default.
- W2021194016 cites W1823239284 @default.
- W2021194016 cites W1956829252 @default.
- W2021194016 cites W1968164116 @default.
- W2021194016 cites W1969949124 @default.
- W2021194016 cites W1986772019 @default.
- W2021194016 cites W2000039023 @default.
- W2021194016 cites W2003647849 @default.
- W2021194016 cites W2016790735 @default.
- W2021194016 cites W2028350625 @default.
- W2021194016 cites W2036416670 @default.
- W2021194016 cites W2044431449 @default.
- W2021194016 cites W2056986191 @default.
- W2021194016 cites W2066229649 @default.
- W2021194016 cites W2067691363 @default.
- W2021194016 cites W2115118012 @default.
- W2021194016 cites W2116611793 @default.
- W2021194016 cites W2123022315 @default.
- W2021194016 cites W2127938131 @default.
- W2021194016 cites W2129314512 @default.
- W2021194016 cites W2141428099 @default.
- W2021194016 cites W2153517923 @default.
- W2021194016 cites W2196598502 @default.
- W2021194016 cites W2396170225 @default.
- W2021194016 cites W2406490102 @default.
- W2021194016 cites W311461775 @default.
- W2021194016 cites W4366739564 @default.
- W2021194016 doi "https://doi.org/10.1016/s0092-8674(00)80510-3" @default.
- W2021194016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9267030" @default.
- W2021194016 hasPublicationYear "1997" @default.
- W2021194016 type Work @default.
- W2021194016 sameAs 2021194016 @default.
- W2021194016 citedByCount "96" @default.
- W2021194016 countsByYear W20211940162013 @default.
- W2021194016 countsByYear W20211940162015 @default.
- W2021194016 countsByYear W20211940162016 @default.
- W2021194016 countsByYear W20211940162017 @default.
- W2021194016 countsByYear W20211940162018 @default.
- W2021194016 countsByYear W20211940162019 @default.
- W2021194016 countsByYear W20211940162020 @default.
- W2021194016 countsByYear W20211940162022 @default.
- W2021194016 crossrefType "journal-article" @default.
- W2021194016 hasAuthorship W2021194016A5004067673 @default.
- W2021194016 hasAuthorship W2021194016A5029740494 @default.
- W2021194016 hasAuthorship W2021194016A5031384028 @default.
- W2021194016 hasAuthorship W2021194016A5041557565 @default.
- W2021194016 hasAuthorship W2021194016A5065040724 @default.
- W2021194016 hasAuthorship W2021194016A5076423900 @default.
- W2021194016 hasAuthorship W2021194016A5082597667 @default.
- W2021194016 hasBestOaLocation W20211940161 @default.
- W2021194016 hasConcept C104292427 @default.
- W2021194016 hasConcept C104317684 @default.
- W2021194016 hasConcept C139770010 @default.
- W2021194016 hasConcept C153911025 @default.
- W2021194016 hasConcept C170493617 @default.
- W2021194016 hasConcept C181199279 @default.
- W2021194016 hasConcept C190062978 @default.
- W2021194016 hasConcept C191678065 @default.
- W2021194016 hasConcept C23265538 @default.
- W2021194016 hasConcept C2776165026 @default.
- W2021194016 hasConcept C2777504413 @default.
- W2021194016 hasConcept C2779743957 @default.
- W2021194016 hasConcept C28005876 @default.
- W2021194016 hasConcept C2911069308 @default.
- W2021194016 hasConcept C49039625 @default.
- W2021194016 hasConcept C55493867 @default.
- W2021194016 hasConcept C79879829 @default.
- W2021194016 hasConcept C86803240 @default.
- W2021194016 hasConcept C95444343 @default.
- W2021194016 hasConceptScore W2021194016C104292427 @default.
- W2021194016 hasConceptScore W2021194016C104317684 @default.
- W2021194016 hasConceptScore W2021194016C139770010 @default.
- W2021194016 hasConceptScore W2021194016C153911025 @default.
- W2021194016 hasConceptScore W2021194016C170493617 @default.
- W2021194016 hasConceptScore W2021194016C181199279 @default.
- W2021194016 hasConceptScore W2021194016C190062978 @default.
- W2021194016 hasConceptScore W2021194016C191678065 @default.
- W2021194016 hasConceptScore W2021194016C23265538 @default.
- W2021194016 hasConceptScore W2021194016C2776165026 @default.
- W2021194016 hasConceptScore W2021194016C2777504413 @default.
- W2021194016 hasConceptScore W2021194016C2779743957 @default.