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• W2021196455 abstract "When bone is mechanically loaded fluid shear stress (FSS) is generated as a result of the movement of interstitial fluid across the membranes of osteoblasts and osteocytes. This external mechanical loading stimulates changes in the activity of cytoplasmic signaling molecules and alters gene expression in bone cells. This process, referred to as mechanotransduction, is vital for maintaining bone health in vivo by regulating the balance between bone formation and bone resorption. This current study focuses on the role of focal adhesions, sites of integrin-mediated cellular attachment to the extracellular matrix, and their proposed function as mechanosensors in bone cells. We examined the role of a key component of focal adhesions and of mechanotransduction, focal adhesion kinase (FAK) in regulation of FSS- and tumor necrosis factor-α (TNF-α)-induced activation of nuclear factor-kappa B (NF-κB) signaling in osteoblasts. Immortalized FAK+/+ and FAK−/− osteoblasts were exposed to periods of oscillatory fluid shear stress (OFF) and NF-κB activation was analyzed. We determined that FAK is required for OFF-induced nuclear translocation and activation of NF-κB in osteoblasts. In addition we found that OFF-induced phosphorylation of the IκB kinases (IKKα/β) in both FAK+/+ and FAK−/− osteoblasts, but only FAK+/+ osteoblasts demonstrated the resulting degradation of NF-κB inhibitors IκBα and IκBβ. OFF did not induce the degradation of IκBε or the processing of p105 in either FAK+/+ and FAK−/− osteoblasts. To compare the role of FAK in mediating OFF-induced mechanotransduction to the well characterized activation of NF-κB by inflammatory cytokines, we exposed FAK+/+ and FAK−/− osteoblasts to TNF-α. Interestingly, FAK was not required for TNF-α induced NF-κB activation in osteoblasts. In addition we determined that TNF-α treatment did not induce the degradation of IκBβ as did OFF. These data indicate a novel relationship between FAK and NF-κB activation in osteoblast mechanotransduction and demonstrates that the mechanism of FSS-induced NF-κB activation in osteoblasts differs from the well characterized TNF-α-induced activation." @default.
• W2021196455 created "2016-06-24" @default.
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• W2021196455 date "2000-09-01" @default.
• W2021196455 modified "2023-09-24" @default.
• W2021196455 title "Shear Stress-Induced Cytoskeleton Rearrangement Mediates NF-κB-Dependent Endothelial Expression of ICAM-1" @default.
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• W2021196455 doi "https://doi.org/10.1006/mvre.2000.2260" @default.
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