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- W2021197441 abstract "Behavioural and psychological symptoms, besides neurological disturbances, should be considered as core features of Parkinson’s disease (PD). Apathy and depression need a particular focus, since these clinical dimensions are associated with poorer functional outcome and increase suffering in patients and caregivers. An abundant literature has demonstrated that apathy, considered as a loss of motivation in goal-oriented activities, can be a disturbing syndrome in many patients and therefore needs an accurate assessment and follow-up. Nevertheless, evaluation of apathy has often been limited in the past to cross-sectional studies, with discrepancies in diagnostic tools or with a poor investigation of its relationship to other clinical or cognitive dimensions. In this issue, Santangelo et al. [1] report an original longitudinal study in which they have measured in newly diagnosed PD patients the 2-year evolution of pure apathy (without depression or dementia) and specific neuropsychological dimensions. They demonstrate a specific relationship between loss of motivation and executive deficits, particularly in the interference task of the Stroop test, independently of disease duration and pharmacological treatment. The results of this study are interesting for at least two reasons. First, they reinforce the position of motivational deficits in PD and their possible occurrence at early stages of the disease. Being associated with some neuropsychological deficit that can reveal a dysfunction in specific subcortical-prefrontal circuits, apathy could express a particular phenotype of PD, thus needing more specific care. Secondly, their results suggest that a higher dosage of monoamino-oxidase inhibitor (IMAO) treatment could be associated with a remission of apathy at follow-up. In the absence of labelled treatment for this syndrome, the possible effect of IMAO should be verified in further specifically designed studies. One of the major remaining issues is the lack of consensus about the assessment of motivation – and its deficit – in neuropsychiatric disorders. This can explain why previous studies have provided very different prevalence rates in PD. It is probably more accurate to measure this syndrome both with self-rating scales" @default.
- W2021197441 created "2016-06-24" @default.
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- W2021197441 date "2014-07-04" @default.
- W2021197441 modified "2023-10-18" @default.
- W2021197441 title "What is the position of apathy in Parkinson's disease?" @default.
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- W2021197441 doi "https://doi.org/10.1111/ene.12503" @default.
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