Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021197853> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2021197853 abstract "People with epilepsy die unexpectedly for unknown pathological reasons at a rate 24 times greater than the general population. Such deaths are classified as sudden unexplained death in epilepsy (SUDEP). The etiology of the SUDEP is frequently unclear which prevents the development of a rational treatment of this problem. Mice lacking Kv1.1 Shaker-like potassium channels encoded by the Kcna1 gene exhibit severe seizures and die prematurely. In this article the authors postulated that Kv1.1-potassium deficiency may underlie primary neurogenic cardiac dysfunction and cause SUDEP. EEG–ECG recordings showed that Kcna1-null mice display atrioventricular (AV) conduction blocks, as well as bradycardia and premature ventricular contractions. During seizures the occurrence of AV conduction blocks increased, which might cause SUDEP. Then the authors used atropine and propranolol to block the autonomic nervous system and found that atropine ameliorated AV conduction block indicating excessive parasympathetic tone may cause a neurocardiac defect. There were no changes in Kv1.1-deficient cardiac structure, but extensive Kv1.1 expression in juxtaparanodes of the wild-type vagus nerve, the primary source of parasympathetic input to the heart. The authors concluded that Kv1.1 deficiency leads to impaired neural control of cardiac rhythmicity due in part to aberrant parasympathetic neurotransmission, making Kcna1 a strong candidate gene for causing human SUDEP." @default.
- W2021197853 created "2016-06-24" @default.
- W2021197853 creator A5009613920 @default.
- W2021197853 creator A5037015805 @default.
- W2021197853 date "2012-04-01" @default.
- W2021197853 modified "2023-09-26" @default.
- W2021197853 title "Highlights in basic autonomic neurosciences: Epileptic seizure and sudden death" @default.
- W2021197853 cites W1979315780 @default.
- W2021197853 cites W2016914908 @default.
- W2021197853 cites W2025506434 @default.
- W2021197853 cites W2049310330 @default.
- W2021197853 cites W2069559288 @default.
- W2021197853 cites W2082835125 @default.
- W2021197853 cites W2083893399 @default.
- W2021197853 cites W2124953033 @default.
- W2021197853 doi "https://doi.org/10.1016/j.autneu.2012.01.002" @default.
- W2021197853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22284814" @default.
- W2021197853 hasPublicationYear "2012" @default.
- W2021197853 type Work @default.
- W2021197853 sameAs 2021197853 @default.
- W2021197853 citedByCount "0" @default.
- W2021197853 crossrefType "journal-article" @default.
- W2021197853 hasAuthorship W2021197853A5009613920 @default.
- W2021197853 hasAuthorship W2021197853A5037015805 @default.
- W2021197853 hasConcept C10928738 @default.
- W2021197853 hasConcept C126322002 @default.
- W2021197853 hasConcept C15744967 @default.
- W2021197853 hasConcept C164705383 @default.
- W2021197853 hasConcept C169760540 @default.
- W2021197853 hasConcept C17755696 @default.
- W2021197853 hasConcept C24998067 @default.
- W2021197853 hasConcept C2775859210 @default.
- W2021197853 hasConcept C2777372248 @default.
- W2021197853 hasConcept C2777495988 @default.
- W2021197853 hasConcept C2777953023 @default.
- W2021197853 hasConcept C2778186239 @default.
- W2021197853 hasConcept C2781404750 @default.
- W2021197853 hasConcept C2993353509 @default.
- W2021197853 hasConcept C42219234 @default.
- W2021197853 hasConcept C71924100 @default.
- W2021197853 hasConcept C84393581 @default.
- W2021197853 hasConceptScore W2021197853C10928738 @default.
- W2021197853 hasConceptScore W2021197853C126322002 @default.
- W2021197853 hasConceptScore W2021197853C15744967 @default.
- W2021197853 hasConceptScore W2021197853C164705383 @default.
- W2021197853 hasConceptScore W2021197853C169760540 @default.
- W2021197853 hasConceptScore W2021197853C17755696 @default.
- W2021197853 hasConceptScore W2021197853C24998067 @default.
- W2021197853 hasConceptScore W2021197853C2775859210 @default.
- W2021197853 hasConceptScore W2021197853C2777372248 @default.
- W2021197853 hasConceptScore W2021197853C2777495988 @default.
- W2021197853 hasConceptScore W2021197853C2777953023 @default.
- W2021197853 hasConceptScore W2021197853C2778186239 @default.
- W2021197853 hasConceptScore W2021197853C2781404750 @default.
- W2021197853 hasConceptScore W2021197853C2993353509 @default.
- W2021197853 hasConceptScore W2021197853C42219234 @default.
- W2021197853 hasConceptScore W2021197853C71924100 @default.
- W2021197853 hasConceptScore W2021197853C84393581 @default.
- W2021197853 hasLocation W20211978531 @default.
- W2021197853 hasLocation W20211978532 @default.
- W2021197853 hasOpenAccess W2021197853 @default.
- W2021197853 hasPrimaryLocation W20211978531 @default.
- W2021197853 hasRelatedWork W1975440733 @default.
- W2021197853 hasRelatedWork W2060279210 @default.
- W2021197853 hasRelatedWork W2063228636 @default.
- W2021197853 hasRelatedWork W2166907382 @default.
- W2021197853 hasRelatedWork W2171746923 @default.
- W2021197853 hasRelatedWork W2766309205 @default.
- W2021197853 hasRelatedWork W2768470951 @default.
- W2021197853 hasRelatedWork W2789661527 @default.
- W2021197853 hasRelatedWork W2916001803 @default.
- W2021197853 hasRelatedWork W3185675323 @default.
- W2021197853 isParatext "false" @default.
- W2021197853 isRetracted "false" @default.
- W2021197853 magId "2021197853" @default.
- W2021197853 workType "article" @default.