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• W2021199072 abstract "The role of cytokines in the control of HCMV infection has been studied in THP-1 cells, a macrophage-like cell model and in MRC-5 cells. HCMV replication was studied by immune detection of viral immediate-early antigens (IEA) and virus yield was evaluated in MRC-5 cells by immunoperoxidase staining. Pretreatment of MRC-5 and phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells with IFN-α or IFN-γ for 24 hr prior to the infection reduced the number of infected cells and virus yield. A synergistic anti-CMV activity in synthesis of early proteins was obtained with these cytokines in combination with TNF-α in differentiated THP-1 cells only. Treatment of HCMV-infected differentiated THP-1 cells or MRC-5 cells with IFN-α or IFN-γ alone had no inhibitory effect on virus replication, however the virus yield was reduced with ganciclovir. A synergistic anti-CMV activity in virus yield was obtained only when infected differentiated THP-1 cells were treated with ganciclovir in combination with IFN-γ. The current study shows that IFN-α and IFN-γ can play a role in the reduction of HCMV replication in macrophage-like cells and in the efficiency of therapies with ganciclovir in this cell type and that the anti-CMV effect of cytokines may be different in fibroblasts and in macrophage-like cells." @default.
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• W2021199072 date "1999-12-01" @default.
• W2021199072 modified "2023-09-25" @default.
• W2021199072 title "Role of Interferon Alpha (IFN-α) and Interferon Gamma (IFN-γ) in the Control of the Infection of Monocyte-Like Cells with Human Cytomegalovirus (HCMV)" @default.
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• W2021199072 doi "https://doi.org/10.1111/j.1348-0421.1999.tb03365.x" @default.
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