FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021199485> ?p ?o ?g. }

• W2021199485 endingPage "832" @default.
• W2021199485 startingPage "825" @default.
• W2021199485 abstract "1 Cutaneous resistance arteries (c.r.a.) (internal diameter=240.94±5.42 μm, n=67/25 (number arteries/number animals)) from New Zealand white rabbits were mounted in wire myographs and a normalization procedure followed. 2 Cumulative concentration-response curves (CCRCs) were constructed for the α-adrenoceptor agonists noradrenaline (NA), (R)A61603 and phenylephrine (PE) in the presence of cocaine (3 μM), propranolol (1 μM) and corticosterone (10 μM). The effects of competitive α1-adrenoceptor antagonists, prazosin, WB4101, 5-methyl-urapidil, HV723, BMY7378 and the irreversible α1B selective compound chloroethylclonidine (CEC) were examined versus the potency and maximum response of the c.r.a.s to noradrenaline. 3 The high potency of A-61603 relative to PE has been shown to differentiate both functional and binding site α1A- or α1B-adrenoceptors from α1D-adrenoceptors: A-61603 was 944 times more potent than phenylephrine (at EC50) suggesting the presence of a functional α1A or α1B as opposed to an α1D-subtype. 4 Exposure to chloroethylclonidine (CEC; 100 μM) decreased the maximum response to noradrenaline but did not significantly change noradrenaline sensitivity indicating that a substantial part of noradrenaline-induced vasoconstriction in rabbit cutaneous arteries is CEC-insensitive. 5 The potencies of prazosin (pA2=9.14) and WB4101 (pA2=9.30) indicate the involvement of prazosin-sensitive functional α1-adrenoceptors. The slopes of corresponding Schild plots for prazosin and WB4101 did not include negative unity which implies the possible involvement of more than one functional α1-adrenoceptor subtype in noradrenaline-induced vasoconstriction in rabbit cutaneous resistance arteries. In contrast to this, in the case of 5-methyl-urapidil and HV723, the Schild plot slope parameters were not significantly different from negative unity over the range of concentrations used; the low pA2 value for 5-methylurapidil (7.27) suggests the non-involvement of an α1A- or an α1D-adrenoceptor; the low pA2 value for HV723 (8.47) was similar to that against responses postulated as α1L. 6 We conclude that rabbit cutaneous resistance arteries express a prazosin-sensitive functional α1-adrenoceptor resembling the α1B and another low affinity site for prazosin which on the basis of the functional antagonism produced by HV723 most closely resembles the α1L-adrenoceptor; the low pA2 value for HV723 (8.47) is similar to that against responses postulated as α1L. British Journal of Pharmacology (1997) 122, 825–832; doi:10.1038/sj.bjp.0701451" @default.
• W2021199485 created "2016-06-24" @default.
• W2021199485 creator A5059319160 @default.
• W2021199485 creator A5077176145 @default.
• W2021199485 creator A5080918615 @default.
• W2021199485 date "1997-11-01" @default.
• W2021199485 modified "2023-10-18" @default.
• W2021199485 title "Investigation of <i>α</i> ₁ -adrenoceptor subtypes mediating vasoconstriction in rabbit cutaneous resistance arteries" @default.
• W2021199485 cites W151037412 @default.
• W2021199485 cites W1965861966 @default.
• W2021199485 cites W1970445852 @default.
• W2021199485 cites W1970448079 @default.
• W2021199485 cites W1984840840 @default.
• W2021199485 cites W1997718198 @default.
• W2021199485 cites W2000360015 @default.
• W2021199485 cites W2004400174 @default.
• W2021199485 cites W2004556358 @default.
• W2021199485 cites W2010346714 @default.
• W2021199485 cites W2020404323 @default.
• W2021199485 cites W2023665876 @default.
• W2021199485 cites W2025346855 @default.
• W2021199485 cites W2026619533 @default.
• W2021199485 cites W2028050995 @default.
• W2021199485 cites W2031481729 @default.
• W2021199485 cites W2038724876 @default.
• W2021199485 cites W2042712431 @default.
• W2021199485 cites W2045780777 @default.
• W2021199485 cites W2047480378 @default.
• W2021199485 cites W2047808770 @default.
• W2021199485 cites W2048373362 @default.
• W2021199485 cites W2057971042 @default.
• W2021199485 cites W2060111059 @default.
• W2021199485 cites W2065635008 @default.
• W2021199485 cites W2074415434 @default.
• W2021199485 cites W2075595591 @default.
• W2021199485 cites W2090722082 @default.
• W2021199485 cites W2091221986 @default.
• W2021199485 cites W2092028537 @default.
• W2021199485 cites W2107045443 @default.
• W2021199485 cites W2402968490 @default.
• W2021199485 cites W2419900010 @default.
• W2021199485 doi "https://doi.org/10.1038/sj.bjp.0701451" @default.
• W2021199485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1565007" @default.
• W2021199485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9384497" @default.
• W2021199485 hasPublicationYear "1997" @default.
• W2021199485 type Work @default.
• W2021199485 sameAs 2021199485 @default.
• W2021199485 citedByCount "35" @default.
• W2021199485 countsByYear W20211994852012 @default.
• W2021199485 countsByYear W20211994852013 @default.
• W2021199485 countsByYear W20211994852015 @default.
• W2021199485 countsByYear W20211994852016 @default.
• W2021199485 countsByYear W20211994852020 @default.
• W2021199485 countsByYear W20211994852022 @default.
• W2021199485 countsByYear W20211994852023 @default.
• W2021199485 crossrefType "journal-article" @default.
• W2021199485 hasAuthorship W2021199485A5059319160 @default.
• W2021199485 hasAuthorship W2021199485A5077176145 @default.
• W2021199485 hasAuthorship W2021199485A5080918615 @default.
• W2021199485 hasBestOaLocation W20211994852 @default.
• W2021199485 hasConcept C126322002 @default.
• W2021199485 hasConcept C134018914 @default.
• W2021199485 hasConcept C170493617 @default.
• W2021199485 hasConcept C185592680 @default.
• W2021199485 hasConcept C202751555 @default.
• W2021199485 hasConcept C2776885963 @default.
• W2021199485 hasConcept C2777952589 @default.
• W2021199485 hasConcept C2778151854 @default.
• W2021199485 hasConcept C2778938600 @default.
• W2021199485 hasConcept C2779961880 @default.
• W2021199485 hasConcept C2780253649 @default.
• W2021199485 hasConcept C2780648677 @default.
• W2021199485 hasConcept C55493867 @default.
• W2021199485 hasConcept C57992300 @default.
• W2021199485 hasConcept C71924100 @default.
• W2021199485 hasConcept C75214554 @default.
• W2021199485 hasConcept C84393581 @default.
• W2021199485 hasConceptScore W2021199485C126322002 @default.
• W2021199485 hasConceptScore W2021199485C134018914 @default.
• W2021199485 hasConceptScore W2021199485C170493617 @default.
• W2021199485 hasConceptScore W2021199485C185592680 @default.
• W2021199485 hasConceptScore W2021199485C202751555 @default.
• W2021199485 hasConceptScore W2021199485C2776885963 @default.
• W2021199485 hasConceptScore W2021199485C2777952589 @default.
• W2021199485 hasConceptScore W2021199485C2778151854 @default.
• W2021199485 hasConceptScore W2021199485C2778938600 @default.
• W2021199485 hasConceptScore W2021199485C2779961880 @default.
• W2021199485 hasConceptScore W2021199485C2780253649 @default.
• W2021199485 hasConceptScore W2021199485C2780648677 @default.
• W2021199485 hasConceptScore W2021199485C55493867 @default.
• W2021199485 hasConceptScore W2021199485C57992300 @default.
• W2021199485 hasConceptScore W2021199485C71924100 @default.
• W2021199485 hasConceptScore W2021199485C75214554 @default.
• W2021199485 hasConceptScore W2021199485C84393581 @default.
• W2021199485 hasIssue "5" @default.
• W2021199485 hasLocation W20211994851 @default.
• W2021199485 hasLocation W20211994852 @default.
• W2021199485 hasLocation W20211994853 @default.

• next