FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021199853> ?p ?o ?g. }

• W2021199853 endingPage "1161" @default.
• W2021199853 startingPage "1154" @default.
• W2021199853 abstract "Abstract High-dose endothelial-monocyte activating polypeptide II (EMAP-II), a tumor-derived antiangiogenic cytokine, can sensitize tumor vasculature to the damaging activity of high-dose tumor necrosis factor (TNF)-α. However, this combination cannot be used for systemic treatment of patients because of prohibitive toxicity. We have found that this limitation can be overcome by combining a TNF-targeting strategy with the use of ultra low-dose EMAP-II. Coadministration of 0.1 ng of EMAP-II and 0.1 ng of CNGRCG-TNF (NGR-TNF), a peptide-TNF conjugate able to target tumor blood vessels, inhibited lymphoma and melanoma growth in mice, with no evidence of toxicity. This drug combination induced endothelial cell apoptosis in vivo and, at later time points, caused reduction of vessel density and massive apoptosis of tumor cells. Ligand-directed targeting of TNF was critical because the combination of nontargeted TNF with EMAP-II was inactive in these murine models. The synergism was progressively lost when the dose of EMAP-II was increased in the nanogram to microgram range, supporting the concept that the use of low-dose EMAP-II is critical. Studies on the mechanism of this paradoxical behavior showed that EMAP-II doses &gt;1 ng induce the release of soluble TNF receptor 1 in circulation, a strong counter-regulatory inhibitor of TNF. Tumor vascular targeting with extremely low amounts of these cytokines may represent a new strategy for cancer treatment. [Cancer Res 2008;68(4):1154–61]" @default.
• W2021199853 created "2016-06-24" @default.
• W2021199853 creator A5024437712 @default.
• W2021199853 creator A5040436989 @default.
• W2021199853 creator A5047480096 @default.
• W2021199853 creator A5057238914 @default.
• W2021199853 creator A5060214201 @default.
• W2021199853 creator A5062787367 @default.
• W2021199853 date "2008-02-15" @default.
• W2021199853 modified "2023-10-11" @default.
• W2021199853 title "Synergistic Damage of Tumor Vessels with Ultra Low-Dose Endothelial-Monocyte Activating Polypeptide-II and Neovasculature-Targeted Tumor Necrosis Factor-α" @default.
• W2021199853 cites W1559937222 @default.
• W2021199853 cites W1579598940 @default.
• W2021199853 cites W1605519347 @default.
• W2021199853 cites W1889451488 @default.
• W2021199853 cites W1890068101 @default.
• W2021199853 cites W2020114724 @default.
• W2021199853 cites W2031583328 @default.
• W2021199853 cites W2034336067 @default.
• W2021199853 cites W2035743071 @default.
• W2021199853 cites W2036100907 @default.
• W2021199853 cites W2063254774 @default.
• W2021199853 cites W2083052252 @default.
• W2021199853 cites W2085353286 @default.
• W2021199853 cites W2094406892 @default.
• W2021199853 cites W2120499500 @default.
• W2021199853 cites W2131887263 @default.
• W2021199853 cites W2143670429 @default.
• W2021199853 cites W2145263059 @default.
• W2021199853 cites W2147829987 @default.
• W2021199853 cites W2153161557 @default.
• W2021199853 cites W2162465275 @default.
• W2021199853 cites W2203518391 @default.
• W2021199853 cites W2312296163 @default.
• W2021199853 cites W4240420638 @default.
• W2021199853 cites W4250428608 @default.
• W2021199853 doi "https://doi.org/10.1158/0008-5472.can-07-2085" @default.
• W2021199853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18281491" @default.
• W2021199853 hasPublicationYear "2008" @default.
• W2021199853 type Work @default.
• W2021199853 sameAs 2021199853 @default.
• W2021199853 citedByCount "32" @default.
• W2021199853 countsByYear W20211998532012 @default.
• W2021199853 countsByYear W20211998532013 @default.
• W2021199853 countsByYear W20211998532014 @default.
• W2021199853 countsByYear W20211998532015 @default.
• W2021199853 countsByYear W20211998532016 @default.
• W2021199853 countsByYear W20211998532017 @default.
• W2021199853 countsByYear W20211998532018 @default.
• W2021199853 countsByYear W20211998532020 @default.
• W2021199853 countsByYear W20211998532021 @default.
• W2021199853 crossrefType "journal-article" @default.
• W2021199853 hasAuthorship W2021199853A5024437712 @default.
• W2021199853 hasAuthorship W2021199853A5040436989 @default.
• W2021199853 hasAuthorship W2021199853A5047480096 @default.
• W2021199853 hasAuthorship W2021199853A5057238914 @default.
• W2021199853 hasAuthorship W2021199853A5060214201 @default.
• W2021199853 hasAuthorship W2021199853A5062787367 @default.
• W2021199853 hasConcept C126322002 @default.
• W2021199853 hasConcept C150903083 @default.
• W2021199853 hasConcept C170493617 @default.
• W2021199853 hasConcept C17991360 @default.
• W2021199853 hasConcept C185592680 @default.
• W2021199853 hasConcept C190283241 @default.
• W2021199853 hasConcept C203014093 @default.
• W2021199853 hasConcept C207001950 @default.
• W2021199853 hasConcept C2777658100 @default.
• W2021199853 hasConcept C2778690821 @default.
• W2021199853 hasConcept C2781184567 @default.
• W2021199853 hasConcept C29730261 @default.
• W2021199853 hasConcept C502942594 @default.
• W2021199853 hasConcept C55493867 @default.
• W2021199853 hasConcept C71924100 @default.
• W2021199853 hasConcept C86803240 @default.
• W2021199853 hasConcept C98274493 @default.
• W2021199853 hasConceptScore W2021199853C126322002 @default.
• W2021199853 hasConceptScore W2021199853C150903083 @default.
• W2021199853 hasConceptScore W2021199853C170493617 @default.
• W2021199853 hasConceptScore W2021199853C17991360 @default.
• W2021199853 hasConceptScore W2021199853C185592680 @default.
• W2021199853 hasConceptScore W2021199853C190283241 @default.
• W2021199853 hasConceptScore W2021199853C203014093 @default.
• W2021199853 hasConceptScore W2021199853C207001950 @default.
• W2021199853 hasConceptScore W2021199853C2777658100 @default.
• W2021199853 hasConceptScore W2021199853C2778690821 @default.
• W2021199853 hasConceptScore W2021199853C2781184567 @default.
• W2021199853 hasConceptScore W2021199853C29730261 @default.
• W2021199853 hasConceptScore W2021199853C502942594 @default.
• W2021199853 hasConceptScore W2021199853C55493867 @default.
• W2021199853 hasConceptScore W2021199853C71924100 @default.
• W2021199853 hasConceptScore W2021199853C86803240 @default.
• W2021199853 hasConceptScore W2021199853C98274493 @default.
• W2021199853 hasIssue "4" @default.
• W2021199853 hasLocation W20211998531 @default.
• W2021199853 hasLocation W20211998532 @default.
• W2021199853 hasOpenAccess W2021199853 @default.
• W2021199853 hasPrimaryLocation W20211998531 @default.
• W2021199853 hasRelatedWork W1991879524 @default.

• next