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• W2021200545 endingPage "e1001420" @default.
• W2021200545 startingPage "e1001420" @default.
• W2021200545 abstract "Changes in the physical interaction between cis-regulatory DNA sequences and proteins drive the evolution of gene expression. However, it has proven difficult to accurately quantify evolutionary rates of such binding change or to estimate the relative effects of selection and drift in shaping the binding evolution. Here we examine the genome-wide binding of CTCF in four species of Drosophila separated by between ∼2.5 and 25 million years. CTCF is a highly conserved protein known to be associated with insulator sequences in the genomes of human and Drosophila. Although the binding preference for CTCF is highly conserved, we find that CTCF binding itself is highly evolutionarily dynamic and has adaptively evolved. Between species, binding divergence increased linearly with evolutionary distance, and CTCF binding profiles are diverging rapidly at the rate of 2.22% per million years (Myr). At least 89 new CTCF binding sites have originated in the Drosophila melanogaster genome since the most recent common ancestor with Drosophila simulans. Comparing these data to genome sequence data from 37 different strains of Drosophila melanogaster, we detected signatures of selection in both newly gained and evolutionarily conserved binding sites. Newly evolved CTCF binding sites show a significantly stronger signature for positive selection than older sites. Comparative gene expression profiling revealed that expression divergence of genes adjacent to CTCF binding site is significantly associated with the gain and loss of CTCF binding. Further, the birth of new genes is associated with the birth of new CTCF binding sites. Our data indicate that binding of Drosophila CTCF protein has evolved under natural selection, and CTCF binding evolution has shaped both the evolution of gene expression and genome evolution during the birth of new genes." @default.
• W2021200545 created "2016-06-24" @default.
• W2021200545 creator A5006842195 @default.
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• W2021200545 creator A5077864427 @default.
• W2021200545 creator A5083785293 @default.
• W2021200545 date "2012-11-06" @default.
• W2021200545 modified "2023-10-07" @default.
• W2021200545 title "Adaptive Evolution and the Birth of CTCF Binding Sites in the Drosophila Genome" @default.
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• W2021200545 cites W1964895626 @default.
• W2021200545 cites W1971977350 @default.
• W2021200545 cites W1973342161 @default.
• W2021200545 cites W1973726475 @default.
• W2021200545 cites W1982603712 @default.
• W2021200545 cites W1987229243 @default.
• W2021200545 cites W1987301268 @default.
• W2021200545 cites W1987553882 @default.
• W2021200545 cites W1988871238 @default.
• W2021200545 cites W1989373989 @default.
• W2021200545 cites W1992224549 @default.
• W2021200545 cites W1998271864 @default.
• W2021200545 cites W2012354488 @default.
• W2021200545 cites W2016206397 @default.
• W2021200545 cites W2020749481 @default.
• W2021200545 cites W2021341670 @default.
• W2021200545 cites W2021798161 @default.
• W2021200545 cites W2023504176 @default.
• W2021200545 cites W2026398852 @default.
• W2021200545 cites W2027781138 @default.
• W2021200545 cites W2029722028 @default.
• W2021200545 cites W2033141201 @default.
• W2021200545 cites W2037594820 @default.
• W2021200545 cites W2038774969 @default.
• W2021200545 cites W2046233233 @default.
• W2021200545 cites W2051001559 @default.
• W2021200545 cites W2053283145 @default.
• W2021200545 cites W2059805279 @default.
• W2021200545 cites W2070168243 @default.
• W2021200545 cites W2074531605 @default.
• W2021200545 cites W2078526277 @default.
• W2021200545 cites W2084728047 @default.
• W2021200545 cites W2085509761 @default.
• W2021200545 cites W2088016816 @default.
• W2021200545 cites W2089434733 @default.
• W2021200545 cites W2091303550 @default.
• W2021200545 cites W2095005830 @default.
• W2021200545 cites W2097220641 @default.
• W2021200545 cites W2099762535 @default.
• W2021200545 cites W2100509209 @default.
• W2021200545 cites W2105381419 @default.
• W2021200545 cites W2110884134 @default.
• W2021200545 cites W2113623526 @default.
• W2021200545 cites W2115325942 @default.
• W2021200545 cites W2118581428 @default.
• W2021200545 cites W2118781875 @default.
• W2021200545 cites W2119708931 @default.
• W2021200545 cites W2121211805 @default.
• W2021200545 cites W2121411802 @default.
• W2021200545 cites W2122774081 @default.
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• W2021200545 cites W2136982019 @default.
• W2021200545 cites W2137015675 @default.
• W2021200545 cites W2139412202 @default.
• W2021200545 cites W2139818536 @default.
• W2021200545 cites W2140538490 @default.
• W2021200545 cites W2140784970 @default.
• W2021200545 cites W2140952049 @default.
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• W2021200545 cites W2156431476 @default.
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• W2021200545 doi "https://doi.org/10.1371/journal.pbio.1001420" @default.
• W2021200545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3491045" @default.
• W2021200545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23139640" @default.
• W2021200545 hasPublicationYear "2012" @default.
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