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• W2021207274 abstract "To better characterize acute myeloid leukemia (AML) development in non-obese diabetic (NOD)/severe combined immunodeficiency (SCID) mice, we transplanted samples from patients with AML or KG-1 and EOL-1 cell lines. We found 9/12 primary AML samples and both cell lines to engraft within 2-8 weeks, with 5-80% human cells in bone marrow. Compared with freshly isolated AML cells, percentages of human CD33+, CD38+, CD31+ CD13+ or CD15+ subpopulations increased after transplantation, whereas percentages of CD34+ cells decreased. Engrafted mice frequently showed expression of human endothelial cell markers. Thus, transplantation of human AML into NOD/SCID mice reveals expression of hematopoietic and endothelial differentiation markers." @default.
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• W2021207274 date "2005-10-01" @default.
• W2021207274 modified "2023-10-16" @default.
• W2021207274 title "Transplantation of human acute myeloid leukemia (AML) cells in immunodeficient mice reveals altered cell surface phenotypes and expression of human endothelial markers" @default.
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• W2021207274 doi "https://doi.org/10.1016/j.leukres.2005.03.019" @default.
• W2021207274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15941586" @default.
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