FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021243075> ?p ?o ?g. }

• W2021243075 endingPage "1719" @default.
• W2021243075 startingPage "1719" @default.
• W2021243075 abstract "The effects of postnatal hypothyroidism on retinal development and spatial patterning of cone opsin expression were studied in Pax8-deficient mice. Pax8(-/-) mice are incapable of synthesizing thyroxine and serve as a model for congenital hypothyroidism.Pax8(-/-), Pax8(+/-), and Pax8(+/+) littermates were studied. Serum thyroid hormone levels, body weight, and eye size were measured. Retinal cell-type-specific antibodies were used on frozen sections to examine the postnatal development of the major retinal cell classes and of retinal structure. The expression of short-wavelength-sensitive (S) and middle-to-long-wavelength-sensitive (M) cone opsins was assessed with opsin antibodies on retinal sections and whole retinas. The pattern of S opsin mRNA was assessed by in situ hybridization.In Pax8(-/-) mice, S opsin was upregulated in all cones, whereas M opsin was downregulated throughout the retina, the wild-type dorsoventral gradients of S and M opsin expression were absent. Otherwise, Pax8(-/-) mice showed no overt mutant phenotype in eye size, gross retinal anatomy, and the time-course of structural differentiation of retinal photoreceptors, horizontal cells, bipolars, amacrines, ganglion cells, and Müller glia cells.Pax8(-/-) mice show a pattern of cone opsin expression that differs substantially from the wild-type pattern, but exhibit no apparent alterations in general retinal development. The finding that a postnatal decrease in serum thyroid hormone yields changes in postnatal cone opsin expression is consistent with a ligand-dependent role of thyroid hormone receptor beta2 in S opsin repression and M opsin activation." @default.
• W2021243075 created "2016-06-24" @default.
• W2021243075 creator A5046361606 @default.
• W2021243075 creator A5059259482 @default.
• W2021243075 creator A5084611542 @default.
• W2021243075 date "2010-03-01" @default.
• W2021243075 modified "2023-09-23" @default.
• W2021243075 title "Developmental Changes of Cone Opsin Expression but Not Retinal Morphology in the Hypothyroid Pax8 Knockout Mouse" @default.
• W2021243075 cites W1491399076 @default.
• W2021243075 cites W1534238736 @default.
• W2021243075 cites W1949058257 @default.
• W2021243075 cites W1967825747 @default.
• W2021243075 cites W1977157996 @default.
• W2021243075 cites W1977986304 @default.
• W2021243075 cites W1982498248 @default.
• W2021243075 cites W1983496424 @default.
• W2021243075 cites W1992618284 @default.
• W2021243075 cites W1995043049 @default.
• W2021243075 cites W1997693108 @default.
• W2021243075 cites W1999305886 @default.
• W2021243075 cites W2006137582 @default.
• W2021243075 cites W2008813184 @default.
• W2021243075 cites W2015260011 @default.
• W2021243075 cites W2015368612 @default.
• W2021243075 cites W2021507484 @default.
• W2021243075 cites W2030319714 @default.
• W2021243075 cites W2033231791 @default.
• W2021243075 cites W2044824418 @default.
• W2021243075 cites W2046171425 @default.
• W2021243075 cites W2059679976 @default.
• W2021243075 cites W2066837860 @default.
• W2021243075 cites W2067204690 @default.
• W2021243075 cites W2069790062 @default.
• W2021243075 cites W2071221837 @default.
• W2021243075 cites W2071810501 @default.
• W2021243075 cites W2074291264 @default.
• W2021243075 cites W2074823355 @default.
• W2021243075 cites W2077520670 @default.
• W2021243075 cites W2082177594 @default.
• W2021243075 cites W2088871053 @default.
• W2021243075 cites W2099545629 @default.
• W2021243075 cites W2104881671 @default.
• W2021243075 cites W2109724812 @default.
• W2021243075 cites W2110999603 @default.
• W2021243075 cites W2120035631 @default.
• W2021243075 cites W2120420989 @default.
• W2021243075 cites W2136512065 @default.
• W2021243075 cites W2167058119 @default.
• W2021243075 cites W2169249307 @default.
• W2021243075 cites W2411181147 @default.
• W2021243075 cites W2269365309 @default.
• W2021243075 doi "https://doi.org/10.1167/iovs.09-3592" @default.
• W2021243075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19834026" @default.
• W2021243075 hasPublicationYear "2010" @default.
• W2021243075 type Work @default.
• W2021243075 sameAs 2021243075 @default.
• W2021243075 citedByCount "36" @default.
• W2021243075 countsByYear W20212430752012 @default.
• W2021243075 countsByYear W20212430752013 @default.
• W2021243075 countsByYear W20212430752014 @default.
• W2021243075 countsByYear W20212430752015 @default.
• W2021243075 countsByYear W20212430752016 @default.
• W2021243075 countsByYear W20212430752017 @default.
• W2021243075 countsByYear W20212430752018 @default.
• W2021243075 countsByYear W20212430752019 @default.
• W2021243075 countsByYear W20212430752020 @default.
• W2021243075 countsByYear W20212430752021 @default.
• W2021243075 countsByYear W20212430752022 @default.
• W2021243075 countsByYear W20212430752023 @default.
• W2021243075 crossrefType "journal-article" @default.
• W2021243075 hasAuthorship W2021243075A5046361606 @default.
• W2021243075 hasAuthorship W2021243075A5059259482 @default.
• W2021243075 hasAuthorship W2021243075A5084611542 @default.
• W2021243075 hasConcept C104317684 @default.
• W2021243075 hasConcept C124224327 @default.
• W2021243075 hasConcept C126322002 @default.
• W2021243075 hasConcept C134018914 @default.
• W2021243075 hasConcept C169760540 @default.
• W2021243075 hasConcept C189780591 @default.
• W2021243075 hasConcept C202033177 @default.
• W2021243075 hasConcept C2777093970 @default.
• W2021243075 hasConcept C2780827179 @default.
• W2021243075 hasConcept C30028475 @default.
• W2021243075 hasConcept C3449773 @default.
• W2021243075 hasConcept C526584372 @default.
• W2021243075 hasConcept C54355233 @default.
• W2021243075 hasConcept C55493867 @default.
• W2021243075 hasConcept C71924100 @default.
• W2021243075 hasConcept C86339819 @default.
• W2021243075 hasConcept C86803240 @default.
• W2021243075 hasConcept C95444343 @default.
• W2021243075 hasConceptScore W2021243075C104317684 @default.
• W2021243075 hasConceptScore W2021243075C124224327 @default.
• W2021243075 hasConceptScore W2021243075C126322002 @default.
• W2021243075 hasConceptScore W2021243075C134018914 @default.
• W2021243075 hasConceptScore W2021243075C169760540 @default.
• W2021243075 hasConceptScore W2021243075C189780591 @default.
• W2021243075 hasConceptScore W2021243075C202033177 @default.

• next