FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021247734> ?p ?o ?g. }

• W2021247734 endingPage "8870" @default.
• W2021247734 startingPage "8862" @default.
• W2021247734 abstract "The cell wall complex in mycobacteria, including the human pathogen Mycobacterium tuberculosis, is comprised in large part of two polysaccharides that contain a significant number of arabinofuranose residues. Both polysaccharides are assembled by a family of arabinosyltransferases that use decaprenolphosphoarabinose (3) as the donor species. In this paper, we describe the synthesis of a panel of C-phosphonate analogues of 3, which were designed to inhibit these arabinosyltransferases and thus block the biosynthesis of mycobacterial cell wall polysaccharides. A number of routes were explored for the preparation of the targets. The successful approach involved the synthesis of a protected C-phosphonate allyl ester 16, which was then coupled to an alkene via an olefin cross metathesis reaction. Subsequent reduction of the alkene with diimide and deprotection afforded the targets. Screening of these compounds in vitro against Mycobacterium tuberculosis revealed that one of the compounds, 15f, possessed antituberculosis activity, with an MIC value of 3.13 μg/mL." @default.
• W2021247734 created "2016-06-24" @default.
• W2021247734 creator A5005404612 @default.
• W2021247734 creator A5059567829 @default.
• W2021247734 date "2002-11-08" @default.
• W2021247734 modified "2023-10-16" @default.
• W2021247734 title "Synthesis and Antituberculosis Activity of C-Phosphonate Analogues of Decaprenolphosphoarabinose, a Key Intermediate in the Biosynthesis of Mycobacterial Arabinogalactan and Lipoarabinomannan" @default.
• W2021247734 cites W1963503284 @default.
• W2021247734 cites W1971087365 @default.
• W2021247734 cites W1979542780 @default.
• W2021247734 cites W1980298554 @default.
• W2021247734 cites W1986885241 @default.
• W2021247734 cites W1998193230 @default.
• W2021247734 cites W1998563168 @default.
• W2021247734 cites W2001200876 @default.
• W2021247734 cites W2004813822 @default.
• W2021247734 cites W2006694606 @default.
• W2021247734 cites W2021669951 @default.
• W2021247734 cites W2023052380 @default.
• W2021247734 cites W2025845302 @default.
• W2021247734 cites W2049915200 @default.
• W2021247734 cites W2057702685 @default.
• W2021247734 cites W2063272824 @default.
• W2021247734 cites W2063776415 @default.
• W2021247734 cites W2068598382 @default.
• W2021247734 cites W2078902026 @default.
• W2021247734 cites W2081206347 @default.
• W2021247734 cites W2089835840 @default.
• W2021247734 cites W2098425249 @default.
• W2021247734 cites W2099316731 @default.
• W2021247734 cites W2103282423 @default.
• W2021247734 cites W2119578867 @default.
• W2021247734 cites W2126576359 @default.
• W2021247734 cites W2133262376 @default.
• W2021247734 cites W2140981202 @default.
• W2021247734 cites W2143537616 @default.
• W2021247734 cites W2148717513 @default.
• W2021247734 cites W2156929790 @default.
• W2021247734 cites W2949771064 @default.
• W2021247734 cites W2951621271 @default.
• W2021247734 cites W2951785402 @default.
• W2021247734 cites W2952169910 @default.
• W2021247734 cites W2952226630 @default.
• W2021247734 cites W2953092217 @default.
• W2021247734 doi "https://doi.org/10.1021/jo026247r" @default.
• W2021247734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12467400" @default.
• W2021247734 hasPublicationYear "2002" @default.
• W2021247734 type Work @default.
• W2021247734 sameAs 2021247734 @default.
• W2021247734 citedByCount "55" @default.
• W2021247734 countsByYear W20212477342012 @default.
• W2021247734 countsByYear W20212477342013 @default.
• W2021247734 countsByYear W20212477342014 @default.
• W2021247734 countsByYear W20212477342015 @default.
• W2021247734 countsByYear W20212477342016 @default.
• W2021247734 countsByYear W20212477342017 @default.
• W2021247734 countsByYear W20212477342018 @default.
• W2021247734 countsByYear W20212477342020 @default.
• W2021247734 countsByYear W20212477342021 @default.
• W2021247734 countsByYear W20212477342022 @default.
• W2021247734 crossrefType "journal-article" @default.
• W2021247734 hasAuthorship W2021247734A5005404612 @default.
• W2021247734 hasAuthorship W2021247734A5059567829 @default.
• W2021247734 hasConcept C100817775 @default.
• W2021247734 hasConcept C125235067 @default.
• W2021247734 hasConcept C142724271 @default.
• W2021247734 hasConcept C181199279 @default.
• W2021247734 hasConcept C185592680 @default.
• W2021247734 hasConcept C21951064 @default.
• W2021247734 hasConcept C2776056871 @default.
• W2021247734 hasConcept C2777626080 @default.
• W2021247734 hasConcept C2777975735 @default.
• W2021247734 hasConcept C2778691952 @default.
• W2021247734 hasConcept C2781069245 @default.
• W2021247734 hasConcept C35753019 @default.
• W2021247734 hasConcept C553450214 @default.
• W2021247734 hasConcept C55493867 @default.
• W2021247734 hasConcept C71240020 @default.
• W2021247734 hasConcept C71924100 @default.
• W2021247734 hasConcept C86803240 @default.
• W2021247734 hasConcept C89423630 @default.
• W2021247734 hasConceptScore W2021247734C100817775 @default.
• W2021247734 hasConceptScore W2021247734C125235067 @default.
• W2021247734 hasConceptScore W2021247734C142724271 @default.
• W2021247734 hasConceptScore W2021247734C181199279 @default.
• W2021247734 hasConceptScore W2021247734C185592680 @default.
• W2021247734 hasConceptScore W2021247734C21951064 @default.
• W2021247734 hasConceptScore W2021247734C2776056871 @default.
• W2021247734 hasConceptScore W2021247734C2777626080 @default.
• W2021247734 hasConceptScore W2021247734C2777975735 @default.
• W2021247734 hasConceptScore W2021247734C2778691952 @default.
• W2021247734 hasConceptScore W2021247734C2781069245 @default.
• W2021247734 hasConceptScore W2021247734C35753019 @default.
• W2021247734 hasConceptScore W2021247734C553450214 @default.
• W2021247734 hasConceptScore W2021247734C55493867 @default.
• W2021247734 hasConceptScore W2021247734C71240020 @default.
• W2021247734 hasConceptScore W2021247734C71924100 @default.
• W2021247734 hasConceptScore W2021247734C86803240 @default.

• next