FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021268697> ?p ?o ?g. }

• W2021268697 endingPage "3569" @default.
• W2021268697 startingPage "3555" @default.
• W2021268697 abstract "A number of studies have shown that the structure and composition of bacterial nucleoid influences many a processes related to DNA metabolism. The nucleoid-associated proteins modulate not only the DNA conformation but also regulate the DNA metabolic processes such as replication, recombination, repair and transcription. Understanding of how these processes occur in the context of Mycobacterium tuberculosis nucleoid is of considerable medical importance because the nucleoid structure may be constantly remodeled in response to environmental signals and/or growth conditions. Many studies have concluded that Escherichia coli H-NS binds to DNA in a sequence-independent manner, with a preference for A-/T-rich tracts in curved DNA; however, recent studies have identified the existence of medium- and low-affinity binding sites in the vicinity of the curved DNA. Here, we show that the M. tuberculosis H-NS protein binds in a more structure-specific manner to DNA replication and repair intermediates, but displays lower affinity for double-stranded DNA with relatively higher GC content. Notably, M. tuberculosis H-NS was able to bind Holliday junction (HJ), the central recombination intermediate, with substantially higher affinity and inhibited the three-strand exchange promoted by its cognate RecA. Likewise, E. coli H-NS was able to bind the HJ and suppress DNA strand exchange promoted by E. coli RecA, although much less efficiently compared to M. tuberculosis H-NS. Our results provide new insights into a previously unrecognized function of H-NS protein, with implications for blocking the genome integration of horizontally transferred genes by homologous and/or homeologous recombination." @default.
• W2021268697 created "2016-06-24" @default.
• W2021268697 creator A5012378530 @default.
• W2021268697 creator A5051983728 @default.
• W2021268697 creator A5063728646 @default.
• W2021268697 creator A5064973504 @default.
• W2021268697 date "2010-02-22" @default.
• W2021268697 modified "2023-10-14" @default.
• W2021268697 title "Mycobacterium tuberculosis nucleoid-associated DNA-binding protein H-NS binds with high-affinity to the Holliday junction and inhibits strand exchange promoted by RecA protein" @default.
• W2021268697 cites W1532845922 @default.
• W2021268697 cites W1571977027 @default.
• W2021268697 cites W1574886161 @default.
• W2021268697 cites W1934147355 @default.
• W2021268697 cites W1966798925 @default.
• W2021268697 cites W1968650445 @default.
• W2021268697 cites W1971558473 @default.
• W2021268697 cites W1975131739 @default.
• W2021268697 cites W1975835222 @default.
• W2021268697 cites W1977890732 @default.
• W2021268697 cites W1985963323 @default.
• W2021268697 cites W1987211465 @default.
• W2021268697 cites W1987697568 @default.
• W2021268697 cites W1992246843 @default.
• W2021268697 cites W1994870083 @default.
• W2021268697 cites W2004690000 @default.
• W2021268697 cites W2005318857 @default.
• W2021268697 cites W2005810531 @default.
• W2021268697 cites W2018775916 @default.
• W2021268697 cites W2018871032 @default.
• W2021268697 cites W2023369350 @default.
• W2021268697 cites W2031257754 @default.
• W2021268697 cites W2033213046 @default.
• W2021268697 cites W2037321511 @default.
• W2021268697 cites W2042902291 @default.
• W2021268697 cites W2045696781 @default.
• W2021268697 cites W2049920155 @default.
• W2021268697 cites W2050814258 @default.
• W2021268697 cites W2057041903 @default.
• W2021268697 cites W2060178110 @default.
• W2021268697 cites W2062139873 @default.
• W2021268697 cites W2063433107 @default.
• W2021268697 cites W2066965664 @default.
• W2021268697 cites W2069816314 @default.
• W2021268697 cites W2072290149 @default.
• W2021268697 cites W2079518832 @default.
• W2021268697 cites W2079561032 @default.
• W2021268697 cites W2081929203 @default.
• W2021268697 cites W2084563793 @default.
• W2021268697 cites W2089059008 @default.
• W2021268697 cites W2093181144 @default.
• W2021268697 cites W2093932681 @default.
• W2021268697 cites W2096779123 @default.
• W2021268697 cites W2096807863 @default.
• W2021268697 cites W2105946796 @default.
• W2021268697 cites W2109771891 @default.
• W2021268697 cites W2110613006 @default.
• W2021268697 cites W2111662566 @default.
• W2021268697 cites W2115083716 @default.
• W2021268697 cites W2115467525 @default.
• W2021268697 cites W2119109353 @default.
• W2021268697 cites W2120772351 @default.
• W2021268697 cites W2123589399 @default.
• W2021268697 cites W2125667231 @default.
• W2021268697 cites W2127552033 @default.
• W2021268697 cites W2129256337 @default.
• W2021268697 cites W2134346985 @default.
• W2021268697 cites W2136440044 @default.
• W2021268697 cites W2138391026 @default.
• W2021268697 cites W2138981653 @default.
• W2021268697 cites W2143856329 @default.
• W2021268697 cites W2145038932 @default.
• W2021268697 cites W2148674110 @default.
• W2021268697 cites W2150990196 @default.
• W2021268697 cites W2154488487 @default.
• W2021268697 cites W2158023121 @default.
• W2021268697 cites W2160174395 @default.
• W2021268697 cites W2162379446 @default.
• W2021268697 cites W2199738362 @default.
• W2021268697 cites W2766746896 @default.
• W2021268697 cites W2884130748 @default.
• W2021268697 cites W4240969190 @default.
• W2021268697 cites W4253858950 @default.
• W2021268697 doi "https://doi.org/10.1093/nar/gkq064" @default.
• W2021268697 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2887947" @default.
• W2021268697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20176569" @default.
• W2021268697 hasPublicationYear "2010" @default.
• W2021268697 type Work @default.
• W2021268697 sameAs 2021268697 @default.
• W2021268697 citedByCount "25" @default.
• W2021268697 countsByYear W20212686972012 @default.
• W2021268697 countsByYear W20212686972013 @default.
• W2021268697 countsByYear W20212686972014 @default.
• W2021268697 countsByYear W20212686972015 @default.
• W2021268697 countsByYear W20212686972016 @default.
• W2021268697 countsByYear W20212686972017 @default.
• W2021268697 countsByYear W20212686972018 @default.
• W2021268697 countsByYear W20212686972021 @default.
• W2021268697 crossrefType "journal-article" @default.

• next