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- W2021279384 abstract "It is safe to say that no one has ever entirely removed the flanking genes from an introgressed region by simple backcrossing — even 100 generations yields only an average introgressed segment length of 2 cM (Silver 1995). The problem of flanking regions has complicated analysis of introgressed genes for some time and is of particular concern for the analysis of complex traits using knockouts, (Gerlai 1996) so it is particularly satisfying to see this slightly vexing phenomenon turned to an advantage in QTL (Quantitative Trait Locus) analysis. In this issue, Bolivar et al. (2001) take advantage of the fact that knockouts are typically generated using ES embryonic stem cells derived from 129 inbred strain and are often backcrossed to C57Bl6 (B6) animals when archived. This convention provides a convenient and growing source of available animals with a small region of 129 chromosome on an otherwise B6 background. The method demonstrated by Bolivar et al. compares the phenotype of B6 animals with the phenotype of B6 animals containing the introgressed 129 region and knockout (B6.129-KO). If there is a difference, the result is followed up with a simple two-part breeding scheme, described in the paper, that separates the effects of the knockout from the effects of the flanking region." @default.
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- W2021279384 date "2001-09-01" @default.
- W2021279384 modified "2023-09-25" @default.
- W2021279384 title "Looking at Old Tools in New Ways: Using Knockouts as Congenics to Study QTLs" @default.
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- W2021279384 doi "https://doi.org/10.1101/gr.206201" @default.
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