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• W2021302549 endingPage "575" @default.
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• W2021302549 abstract "The endocannabinoid system (ECS) has therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced cerebral diseases. This study investigated the protective effects of two ECS compounds, cannabinoid receptor agonist WIN55,212-2 (WIN) and fatty acid amide hydrolase inhibitor URB597 (URB) on CCH-induced neuronal apoptosis in vivo. CCH was induced in male Sprague–Dawley rats by bilateral common carotid artery occlusion (BCCAo); the rats were then treated with WIN or URB for 12 weeks and their spatial learning and memory abilities were assessed using the Morris water maze. Changes in neuronal number were examined by labeling neurons with an antibody against the neuronal nuclei antigen, and apoptosis of cortical and hippocampal CA1 neurons was detected by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. The expression of B cell lymphoma (Bcl)-2, Bcl-2-associated X protein (Bax), and activated caspase-3 as well as mitogen-activated protein kinases including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38, phosphorylated (p-)ERK, p-JNK, and p-P38 was examined by Western blotting. Rats treated with WIN or URB showed better learning and memory performance than controls. The neuroprotective effects of URB were greater than those of WIN, and co-administration of WIN and URB had a synergistic effect. In addition, WIN and URB blocked JNK phosphorylation as well as the decrease in Bcl-2/Bax ratio and caspase-3 activation induced by CCH, implying that these agents modulate neuronal survival. Moreover, the selective JNK inhibitor SP600125 improved mitochondrial membrane dysfunction and blocked neuronal apoptosis induced by JNK-dependent Bcl-2 signaling. WIN and URB enhanced the effects of SP600125, implying that they may exert anti-apoptotic effects in part by inhibiting a non-nuclear JNK pathway. These findings indicate that WIN and URB promote neuronal survival and may potentially be used to protect neurons against chronic ischemic insults." @default.
• W2021302549 created "2016-06-24" @default.
• W2021302549 creator A5005034089 @default.
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• W2021302549 date "2015-08-01" @default.
• W2021302549 modified "2023-10-15" @default.
• W2021302549 title "Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 suppress chronic cerebral hypoperfusion-induced neuronal apoptosis by inhibiting c-Jun N-terminal kinase signaling" @default.
• W2021302549 cites W1529806277 @default.
• W2021302549 cites W1600267881 @default.
• W2021302549 cites W1945839644 @default.
• W2021302549 cites W1959296941 @default.
• W2021302549 cites W1966112595 @default.
• W2021302549 cites W1966824103 @default.
• W2021302549 cites W1969700660 @default.
• W2021302549 cites W1973605151 @default.
• W2021302549 cites W1973905298 @default.
• W2021302549 cites W1976973005 @default.
• W2021302549 cites W1981323788 @default.
• W2021302549 cites W1987823843 @default.
• W2021302549 cites W1994307189 @default.
• W2021302549 cites W1995552285 @default.
• W2021302549 cites W1999713898 @default.
• W2021302549 cites W2001387651 @default.
• W2021302549 cites W2004251274 @default.
• W2021302549 cites W2008283809 @default.
• W2021302549 cites W2009495434 @default.
• W2021302549 cites W2018891331 @default.
• W2021302549 cites W2027688921 @default.
• W2021302549 cites W2028794471 @default.
• W2021302549 cites W2031037143 @default.
• W2021302549 cites W2034673751 @default.
• W2021302549 cites W2039086621 @default.
• W2021302549 cites W2039194462 @default.
• W2021302549 cites W2039964546 @default.
• W2021302549 cites W2040179925 @default.
• W2021302549 cites W2042530543 @default.
• W2021302549 cites W2043228679 @default.
• W2021302549 cites W2047882129 @default.
• W2021302549 cites W2056035231 @default.
• W2021302549 cites W2057833753 @default.
• W2021302549 cites W2059436903 @default.
• W2021302549 cites W2062461652 @default.
• W2021302549 cites W2063953032 @default.
• W2021302549 cites W2064284229 @default.
• W2021302549 cites W2067113295 @default.
• W2021302549 cites W2071695275 @default.
• W2021302549 cites W2071835207 @default.
• W2021302549 cites W2072585950 @default.
• W2021302549 cites W2073592724 @default.
• W2021302549 cites W2073748140 @default.
• W2021302549 cites W2074114778 @default.
• W2021302549 cites W2077491473 @default.
• W2021302549 cites W2077979212 @default.
• W2021302549 cites W2081580584 @default.
• W2021302549 cites W2085935748 @default.
• W2021302549 cites W2086053019 @default.
• W2021302549 cites W2086349524 @default.
• W2021302549 cites W2087877138 @default.
• W2021302549 cites W2088209621 @default.
• W2021302549 cites W2090264642 @default.
• W2021302549 cites W2097045418 @default.
• W2021302549 cites W2098025305 @default.
• W2021302549 cites W2102062227 @default.
• W2021302549 cites W2108877671 @default.
• W2021302549 cites W2121884198 @default.
• W2021302549 cites W2123943796 @default.
• W2021302549 cites W2133859389 @default.
• W2021302549 cites W2136391397 @default.
• W2021302549 cites W2139753812 @default.
• W2021302549 cites W2145252529 @default.
• W2021302549 cites W2157971597 @default.
• W2021302549 cites W2158724089 @default.
• W2021302549 cites W2159155070 @default.
• W2021302549 cites W2159760953 @default.
• W2021302549 cites W2160691778 @default.
• W2021302549 cites W2164973029 @default.
• W2021302549 cites W2166501811 @default.
• W2021302549 cites W2169182197 @default.
• W2021302549 cites W2321316620 @default.
• W2021302549 cites W2614602784 @default.
• W2021302549 cites W4241363254 @default.
• W2021302549 cites W4319293047 @default.
• W2021302549 cites W646114512 @default.
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• W2021302549 doi "https://doi.org/10.1016/j.neuroscience.2015.03.021" @default.
• W2021302549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25795598" @default.
• W2021302549 hasPublicationYear "2015" @default.
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