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• W2021303527 abstract "Enteropathogenic Escherichia coli (EPEC) infection of the human small intestine induces severe watery diarrhoea linked to a rather weak inflammatory response despite EPEC's in vivo capacity to disrupt epithelial barrier function. Here, we demonstrate that EPEC flagellin triggers the secretion of the pro-inflammatory cytokine, interleukin (IL)-8, from small (Caco-2) and large (T84) intestinal epithelia model systems. Interestingly, IL-8 secretion required basolateral infection of T84 cells implying that flagellin must penetrate the epithelial barrier. In contrast, apical infection of Caco-2 cells induced IL-8 secretion but less potently than basolateral infections. Importantly, infection of Caco-2, but not T84 cells rapidly inhibited IL-8 secretion by a mechanism dependent on the delivery of effectors through a translocation system encoded on the locus of enterocyte effacement (LEE). Moreover, EPEC prevents the phosphorylation-associated activation of multiple kinase pathways regulating IL-8 gene transcription by a mechanism apparently independent of LEE-encoded effectors and four non-LEE-encoded effectors. Crucially, our studies reveal that EPEC inhibits the capacity of the cells to secrete IL-8 in response to bacterial antigens and inflammatory cytokines prior to disrupting barrier function by a distinct mechanism. Thus, these findings also lend themselves to a plausible mechanism to explain the absence of a strong inflammatory response in EPEC-infected humans." @default.
• W2021303527 created "2016-06-24" @default.
• W2021303527 creator A5030403752 @default.
• W2021303527 creator A5039559606 @default.
• W2021303527 creator A5065473864 @default.
• W2021303527 date "2007-08-01" @default.
• W2021303527 modified "2023-09-24" @default.
• W2021303527 title "Enteropathogenic Escherichia coli (EPEC) inactivate innate immune responses prior to compromising epithelial barrier function" @default.
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• W2021303527 doi "https://doi.org/10.1111/j.1462-5822.2007.00923.x" @default.
• W2021303527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1974805" @default.
• W2021303527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17388785" @default.
• W2021303527 hasPublicationYear "2007" @default.
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