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- W2021304026 abstract "the number of patients. However, this difference is what one would predict by using a modification of the formula proposed by Suit and Westgate to determine the potential survival benefit from improved local control (21). The survival gain can be calculated by assessing the difference in local control for the two treatments, multiplying this difference by the percentage of patients with local control who develop distant metastases, and subtracting from this number the percentage of patients with a local failure who are salvaged by subsequent treatment. Using data from the Ontario Clinical Oncology Group axillary node negative trial, the 22% improvement in local control (30%8%) would be expected to result in a 4-5% survival benefit. The 5-year actuarial survival after a breast recurrence was 74% and it can be inferred from Figure 3 that approximately 25-30% of patients with local control died from distant metastases. Therefore, the data support the concept that an improvement in local control for node-negative breast cancer may result in a small survival benefit." @default.
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- W2021304026 title "The relationship between local relapse and distant metastases revisited" @default.
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- W2021304026 doi "https://doi.org/10.1016/0360-3016(94)90541-x" @default.
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