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• W2021305862 abstract "An ultrastructural and immunohistochemical study was performed on three malignant lymphomas of follicular center cell origin with signet-ring cells. The first case corresponded to a diffuse lymphoma with follicular center cells and plasmacytic features; the other two cases corresponded to the nodular centrocytic-centroblastic category. The neoplastic lymphocytes contained Russell bodylike inclusions, clear vacuoles, and ill-defined eosinophilic masses, respectively, which produced a displacement of the nuclei to the periphery. Ultrastructurally, there were three different morphologic types because of the following cytoplasmic changes: the accumulation of electron-dense granular material in the cisternae of the rough endoplasmic reticulum; the formation of clear vacuoles with a smooth limiting membrane; and, the presence of granular-fibrillar and crystalline material in the hyaloplasm without a limiting membrane. The first type of signet-ring cell contained monoclonal immunoglobulin (IgM-K). No immunoglobulins were found in the clear cytoplasmic vacuoles of the second type; however, the rim of cytoplasm stained for IgG, kappa and lambda. Finally, the third type showed IgG and kappa light chain in the hyaloplasmic inclusions. It is concluded that the signet-ring cell appearance is due to an abnormal production and secretion of immunoglobulins." @default.
• W2021305862 created "2016-06-24" @default.
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• W2021305862 date "1983-11-01" @default.
• W2021305862 modified "2023-10-16" @default.
• W2021305862 title "Signet-ring cell lymphoma. Ultrastructural and immunohistochemical features of three varieties" @default.
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• W2021305862 doi "https://doi.org/10.1002/1097-0142(19831101)52:9<1613::aid-cncr2820520913>3.0.co;2-v" @default.
• W2021305862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6193861" @default.
• W2021305862 hasPublicationYear "1983" @default.
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