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• W2021306804 abstract "ABSTRACT Some of the earliest studies of retroviral integration targeting reported that sites of gammaretroviral DNA integration were positively correlated with DNase I-hypersensitive sites in chromatin. This led to the suggestion that open chromatin was favorable for integration. More recent deep sequencing experiments confirmed that gammaretroviral integration sites and DNase I cleavage sites are associated in genome-wide surveys. Paradoxically, in vitro studies of integration show that nucleosomal DNA is actually favored over naked DNA, raising the question of whether integration target DNA in chromosomes is wrapped in nucleosomes or nucleosome free. In this study we examined gammaretroviral integration by infecting primary human CD4 + T lymphocytes with a murine leukemia virus (MLV)-based retroviral vector or xenotropic murine leukemia virus-related virus (XMRV), and isolated 32,585 unique integration sites using ligation-mediated PCR and 454 pyrosequencing. CD4 + T lymphocytes were chosen for study because of the particularly dense genome-wide mapping of chromatin features available for comparison. Analysis relative to predicted nucleosome positions showed that gammaretroviruses direct integration into outward-facing major grooves on nucleosome-wrapped DNA, similar to the integration pattern of HIV. Also, a suite of histone modifications correlated with gene activity are positively associated with integration by both MLV and XMRV. Thus, we conclude that favored integration near DNase I-hypersensitive sites does not imply that integration takes place exclusively in nucleosome-free regions." @default.
• W2021306804 created "2016-06-24" @default.
• W2021306804 creator A5005104278 @default.
• W2021306804 creator A5019388295 @default.
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• W2021306804 date "2011-07-15" @default.
• W2021306804 modified "2023-09-23" @default.
• W2021306804 title "Gammaretroviral Integration into Nucleosomal Target DNA <i>In Vivo</i>" @default.
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• W2021306804 doi "https://doi.org/10.1128/jvi.00635-11" @default.
• W2021306804 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3126552" @default.
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• W2021306804 hasPublicationYear "2011" @default.
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