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- W2021307584 abstract "<i>Background:</i> Japanese cedar pollinosis is the most common form of hay fever in spring in Japan. We have previously demonstrated that single nucleotide polymorphism Pro358Leu of exon 7 in the eosinophil peroxidase (EPO) gene is associated with cedar pollinosis, although the association has not been confirmed by analysis of the whole gene in a different population. <i>Methods:</i> We sequenced all exons of the EPO gene in 60 children with pollinosis and their parents using the PCR-restriction fragment length polymorphism method. <i>Results:</i> We found 8 polymorphisms, Ile40Met, Gln122His, Arg202Arg (A660G), Asn303Asn (C909T), Arg326Pro, Arg326His, Pro358Leu, and Asn572Ty, in the EPO gene. As a result of the transmission disequilibrium test, we recognized significant transmissions of 202Arg (660G) in exon 6 in addition to 358Leu of exon 7 in the EPO gene of affected children. <i>Conclusions:</i> Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis." @default.
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- W2021307584 date "2004-01-01" @default.
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- W2021307584 title "Association of Single Nucleotide Polymorphisms in the Eosinophil Peroxidase Gene with Japanese Cedar Pollinosis" @default.
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- W2021307584 doi "https://doi.org/10.1159/000080222" @default.
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