FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021307726> ?p ?o ?g. }

• W2021307726 endingPage "1716" @default.
• W2021307726 startingPage "1710" @default.
• W2021307726 abstract "Introduction/Purpose: Regular aerobic exercise reduces aortic stiffness. However, the mechanisms by which chronic exercise lowers arterial stiffness are not known. To determine the molecular mechanisms of these changes, the alteration of gene expression in the aorta by aerobic exercise training was measured with the microarray technique. Methods/Results: The differences in expression levels of 3800 genes in the abdominal aorta of sedentary control rats (8 wk old) and exercise-trained rats (8 wk old, treadmill running for 4 wk) were compared by the microarray analysis. Aortic pulse wave velocity (PWV) was lower and systemic arterial compliance was higher (both P < 0.05) in the exercise-trained group than in the control group. Of the 323 genes that displayed differential expression (upregulation of 206 genes and downregulation of 117 genes), a total of 29 genes (24 upregulated and 5 downregulated genes) were identified as potential candidate genes that may be involved in vasodilation and arterial destiffening. Using real-time quantitative polymerase chain reaction, we confirmed the results of microarray analysis that prostaglandin EP2 receptor (PGE-EP2R), prostaglandin EP4 receptor (PGE-EP4R), C-type natriuretic peptide (CNP), and endothelial nitric oxide synthase (eNOS) genes were differentially expressed. Furthermore, there were modest correlations between arterial stiffness and levels of these factors. Differential expression of eNOS gene was further verified at protein level by using Western blot analysis. Conclusion: These results suggest that exercise training induces the altered expression in several genes including prostaglandin, CNP, and nitric oxide in the aorta and that these molecular changes (particularly eNOS as its protein expression was altered) may contribute, at least in part, to the beneficial effect of exercise training on aortic stiffness." @default.
• W2021307726 created "2016-06-24" @default.
• W2021307726 creator A5029645405 @default.
• W2021307726 creator A5041403109 @default.
• W2021307726 creator A5051013835 @default.
• W2021307726 creator A5052073274 @default.
• W2021307726 creator A5055426703 @default.
• W2021307726 creator A5064689365 @default.
• W2021307726 date "2005-10-01" @default.
• W2021307726 modified "2023-10-11" @default.
• W2021307726 title "Aortic Stiffness and Aerobic Exercise: Mechanistic Insight from Microarray Analyses" @default.
• W2021307726 cites W1640867508 @default.
• W2021307726 cites W1916944394 @default.
• W2021307726 cites W1925607687 @default.
• W2021307726 cites W2002879009 @default.
• W2021307726 cites W2006550171 @default.
• W2021307726 cites W2012651045 @default.
• W2021307726 cites W2014951227 @default.
• W2021307726 cites W2037177246 @default.
• W2021307726 cites W2068414981 @default.
• W2021307726 cites W2074862244 @default.
• W2021307726 cites W2084313392 @default.
• W2021307726 cites W2093392163 @default.
• W2021307726 cites W2099876687 @default.
• W2021307726 cites W2114882367 @default.
• W2021307726 cites W2118206922 @default.
• W2021307726 cites W2122591361 @default.
• W2021307726 cites W2125823894 @default.
• W2021307726 cites W2136503561 @default.
• W2021307726 cites W2139198236 @default.
• W2021307726 cites W2145684092 @default.
• W2021307726 cites W2156931498 @default.
• W2021307726 cites W2164649219 @default.
• W2021307726 cites W2231840105 @default.
• W2021307726 cites W2417974592 @default.
• W2021307726 cites W954944586 @default.
• W2021307726 doi "https://doi.org/10.1249/01.mss.0000175052.37087.f8" @default.
• W2021307726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16260970" @default.
• W2021307726 hasPublicationYear "2005" @default.
• W2021307726 type Work @default.
• W2021307726 sameAs 2021307726 @default.
• W2021307726 citedByCount "60" @default.
• W2021307726 countsByYear W20213077262012 @default.
• W2021307726 countsByYear W20213077262013 @default.
• W2021307726 countsByYear W20213077262014 @default.
• W2021307726 countsByYear W20213077262015 @default.
• W2021307726 countsByYear W20213077262016 @default.
• W2021307726 countsByYear W20213077262017 @default.
• W2021307726 countsByYear W20213077262018 @default.
• W2021307726 countsByYear W20213077262019 @default.
• W2021307726 countsByYear W20213077262020 @default.
• W2021307726 countsByYear W20213077262021 @default.
• W2021307726 countsByYear W20213077262022 @default.
• W2021307726 countsByYear W20213077262023 @default.
• W2021307726 crossrefType "journal-article" @default.
• W2021307726 hasAuthorship W2021307726A5029645405 @default.
• W2021307726 hasAuthorship W2021307726A5041403109 @default.
• W2021307726 hasAuthorship W2021307726A5051013835 @default.
• W2021307726 hasAuthorship W2021307726A5052073274 @default.
• W2021307726 hasAuthorship W2021307726A5055426703 @default.
• W2021307726 hasAuthorship W2021307726A5064689365 @default.
• W2021307726 hasBestOaLocation W20213077261 @default.
• W2021307726 hasConcept C103038586 @default.
• W2021307726 hasConcept C104317684 @default.
• W2021307726 hasConcept C126322002 @default.
• W2021307726 hasConcept C127561419 @default.
• W2021307726 hasConcept C134018914 @default.
• W2021307726 hasConcept C150194340 @default.
• W2021307726 hasConcept C185592680 @default.
• W2021307726 hasConcept C186836561 @default.
• W2021307726 hasConcept C2775850156 @default.
• W2021307726 hasConcept C2777622882 @default.
• W2021307726 hasConcept C2778319312 @default.
• W2021307726 hasConcept C2778326061 @default.
• W2021307726 hasConcept C519581460 @default.
• W2021307726 hasConcept C55493867 @default.
• W2021307726 hasConcept C71924100 @default.
• W2021307726 hasConcept C8415881 @default.
• W2021307726 hasConcept C84393581 @default.
• W2021307726 hasConceptScore W2021307726C103038586 @default.
• W2021307726 hasConceptScore W2021307726C104317684 @default.
• W2021307726 hasConceptScore W2021307726C126322002 @default.
• W2021307726 hasConceptScore W2021307726C127561419 @default.
• W2021307726 hasConceptScore W2021307726C134018914 @default.
• W2021307726 hasConceptScore W2021307726C150194340 @default.
• W2021307726 hasConceptScore W2021307726C185592680 @default.
• W2021307726 hasConceptScore W2021307726C186836561 @default.
• W2021307726 hasConceptScore W2021307726C2775850156 @default.
• W2021307726 hasConceptScore W2021307726C2777622882 @default.
• W2021307726 hasConceptScore W2021307726C2778319312 @default.
• W2021307726 hasConceptScore W2021307726C2778326061 @default.
• W2021307726 hasConceptScore W2021307726C519581460 @default.
• W2021307726 hasConceptScore W2021307726C55493867 @default.
• W2021307726 hasConceptScore W2021307726C71924100 @default.
• W2021307726 hasConceptScore W2021307726C8415881 @default.
• W2021307726 hasConceptScore W2021307726C84393581 @default.
• W2021307726 hasIssue "10" @default.
• W2021307726 hasLocation W20213077261 @default.

• next