Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021308137> ?p ?o ?g. }
- W2021308137 endingPage "386" @default.
- W2021308137 startingPage "377" @default.
- W2021308137 abstract "A bstract : Bone marrow transplantation (BMT) Is currently a procedure that Is associated with high morbility and mortality. Thus, The clinical application of this technique is limited to the treatment of life‐threatening hematopoietic malignancies. The morbility and mortality of BMT is mainly related to graft‐versus‐host disease (GVHD), failure of engraftment, and toxicity related to fully myeloablative conditioning. GVHD can be prevented by T‐cell depletion. However, T‐cell depletion increases the risk of failure of engraftment. With the identification of a facilitating cell population that enables engraftment of hematopoietic stem cells across major histocompatibility barriers, the dichotomy between GVHD and failure of engraftment has been resolved. If one could overcome the toxicity of conditioning with the development of partially ablative conditioning strategies, BMT could be used for the treatment of a variety of nonmalignent diseases, as well as in the induction of donor‐specific transplantation tolerance. This review outlines the development and advantages of partially ablative conditioning strategies and illustrates possible applications of the technique. Forty years ago E.D. Thomas discussed the potential of BMT for treating immunodeficiencies and for the induction of transplantation tolerance. 1 BMT can be viewed as a natural form of gene therapy to replace a defective cell or enzyme with a functional and normally regulated one." @default.
- W2021308137 created "2016-06-24" @default.
- W2021308137 creator A5009753759 @default.
- W2021308137 creator A5012869970 @default.
- W2021308137 creator A5024636895 @default.
- W2021308137 creator A5051022402 @default.
- W2021308137 creator A5060383525 @default.
- W2021308137 date "1999-04-01" @default.
- W2021308137 modified "2023-09-27" @default.
- W2021308137 title "Clinical Applications of Mixed Chimerism" @default.
- W2021308137 cites W1508187469 @default.
- W2021308137 cites W1569581528 @default.
- W2021308137 cites W1596160021 @default.
- W2021308137 cites W1649565553 @default.
- W2021308137 cites W1900958902 @default.
- W2021308137 cites W1929691604 @default.
- W2021308137 cites W1965239953 @default.
- W2021308137 cites W1967702267 @default.
- W2021308137 cites W1971159655 @default.
- W2021308137 cites W1978820949 @default.
- W2021308137 cites W1985889898 @default.
- W2021308137 cites W1989791334 @default.
- W2021308137 cites W2013436922 @default.
- W2021308137 cites W2014993931 @default.
- W2021308137 cites W2015322864 @default.
- W2021308137 cites W2024604633 @default.
- W2021308137 cites W2039801541 @default.
- W2021308137 cites W2064430381 @default.
- W2021308137 cites W2064457820 @default.
- W2021308137 cites W2066526517 @default.
- W2021308137 cites W2068653310 @default.
- W2021308137 cites W2075580305 @default.
- W2021308137 cites W2079714040 @default.
- W2021308137 cites W2096648897 @default.
- W2021308137 cites W2110272001 @default.
- W2021308137 cites W2141021930 @default.
- W2021308137 cites W2152918507 @default.
- W2021308137 cites W2324143840 @default.
- W2021308137 cites W62199461 @default.
- W2021308137 doi "https://doi.org/10.1111/j.1749-6632.1999.tb08482.x" @default.
- W2021308137 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10372140" @default.
- W2021308137 hasPublicationYear "1999" @default.
- W2021308137 type Work @default.
- W2021308137 sameAs 2021308137 @default.
- W2021308137 citedByCount "11" @default.
- W2021308137 crossrefType "journal-article" @default.
- W2021308137 hasAuthorship W2021308137A5009753759 @default.
- W2021308137 hasAuthorship W2021308137A5012869970 @default.
- W2021308137 hasAuthorship W2021308137A5024636895 @default.
- W2021308137 hasAuthorship W2021308137A5051022402 @default.
- W2021308137 hasAuthorship W2021308137A5060383525 @default.
- W2021308137 hasConcept C104317684 @default.
- W2021308137 hasConcept C109159458 @default.
- W2021308137 hasConcept C111599444 @default.
- W2021308137 hasConcept C126322002 @default.
- W2021308137 hasConcept C147483822 @default.
- W2021308137 hasConcept C188280979 @default.
- W2021308137 hasConcept C202965653 @default.
- W2021308137 hasConcept C203014093 @default.
- W2021308137 hasConcept C2777408962 @default.
- W2021308137 hasConcept C2779134260 @default.
- W2021308137 hasConcept C2780007613 @default.
- W2021308137 hasConcept C28328180 @default.
- W2021308137 hasConcept C2908647359 @default.
- W2021308137 hasConcept C2911091166 @default.
- W2021308137 hasConcept C54355233 @default.
- W2021308137 hasConcept C71924100 @default.
- W2021308137 hasConcept C86803240 @default.
- W2021308137 hasConcept C99454951 @default.
- W2021308137 hasConceptScore W2021308137C104317684 @default.
- W2021308137 hasConceptScore W2021308137C109159458 @default.
- W2021308137 hasConceptScore W2021308137C111599444 @default.
- W2021308137 hasConceptScore W2021308137C126322002 @default.
- W2021308137 hasConceptScore W2021308137C147483822 @default.
- W2021308137 hasConceptScore W2021308137C188280979 @default.
- W2021308137 hasConceptScore W2021308137C202965653 @default.
- W2021308137 hasConceptScore W2021308137C203014093 @default.
- W2021308137 hasConceptScore W2021308137C2777408962 @default.
- W2021308137 hasConceptScore W2021308137C2779134260 @default.
- W2021308137 hasConceptScore W2021308137C2780007613 @default.
- W2021308137 hasConceptScore W2021308137C28328180 @default.
- W2021308137 hasConceptScore W2021308137C2908647359 @default.
- W2021308137 hasConceptScore W2021308137C2911091166 @default.
- W2021308137 hasConceptScore W2021308137C54355233 @default.
- W2021308137 hasConceptScore W2021308137C71924100 @default.
- W2021308137 hasConceptScore W2021308137C86803240 @default.
- W2021308137 hasConceptScore W2021308137C99454951 @default.
- W2021308137 hasIssue "1" @default.
- W2021308137 hasLocation W20213081371 @default.
- W2021308137 hasLocation W20213081372 @default.
- W2021308137 hasOpenAccess W2021308137 @default.
- W2021308137 hasPrimaryLocation W20213081371 @default.
- W2021308137 hasRelatedWork W1978598034 @default.
- W2021308137 hasRelatedWork W2038751426 @default.
- W2021308137 hasRelatedWork W2090080844 @default.
- W2021308137 hasRelatedWork W2162587612 @default.
- W2021308137 hasRelatedWork W2253242983 @default.
- W2021308137 hasRelatedWork W2322919840 @default.