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- W2021308478 abstract "Die autologe Chondrozytenimplantation und Matrix-assistierte Chondrozytenimplantation sind heute anerkannte Operationsverfahren zur Knorpelreparation, sorgen jedoch aufgrund der hohen Kosten und des hohen Aufwands einer zweizeitigen Operation sowie einer teils fibroblastischen Regeneration für Diskussion. Die Entwicklung einer Technik bei der ein Knochenmarkkoagel als biologische autologe Matrix verwendet wird und durch das lokale Einbringen von Wachstumsfaktoren mit Hilfe einer so genannten In-situ-Gentherapie durch die eine Knorpelheilung initiiert wird, ermöglicht eine einzeitige Operation und erspart die hohen Ex-vivo-Kultivierungs- und Transportkosten sowie die Entwicklungs- und Herstellungskosten synthetischer Matrices. The autologous chondrocyte implantation and matrix assisted autologous chondrocyte implantation are world wide accepted procedures to treat cartilage defects. Nevertheless, these methods lead to ongoing discussions due to high costs, the inconvenience of a two step procedure and partial fibrocartilage regeneration. The development of a technique using coagulated bone marrow as an autologous biological matrix to deliver growth factors by in situ gene therapy initiating cartilage repair within the defect offers the possibility of an one step procedure and to cut down the costs of ex vivo culture, transportation of cells as well as the development and production of synthetic matrices." @default.
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- W2021308478 date "2008-06-01" @default.
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- W2021308478 title "Gentherapie in der Knorpelregeneration" @default.
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- W2021308478 doi "https://doi.org/10.1016/j.orthtr.2008.04.007" @default.
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