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- W2021309719 endingPage "4705" @default.
- W2021309719 startingPage "4697" @default.
- W2021309719 abstract "The growing perception that diseases are often consequences of multiple molecular abnormalities rather than being the result of a single defect highlights the importance of network-centric view in therapeutic approaches. Protein interaction networks may contribute to understanding of disease, assist in drug design and discovery. Here, we review some recent advances in disease-associated protein interaction networks taking a structural approach. We first describe structural aspects of protein-protein interactions and properties of protein interfaces as related to drug design; we address protein interactions in a network perspective; in particular, we illustrate how integrating protein interfaces onto interaction networks can guide the identification of selective drug targets or drugs targeting multiple proteins in a network. Keywords: Protein-protein interfaces, protein interaction networks, drug design, drug targets, binding site, interfacial residues, transient, amino acid, Glycine, Cystine-Cystine." @default.
- W2021309719 created "2016-06-24" @default.
- W2021309719 creator A5005856319 @default.
- W2021309719 creator A5035685178 @default.
- W2021309719 creator A5036278069 @default.
- W2021309719 creator A5057115991 @default.
- W2021309719 date "2012-08-23" @default.
- W2021309719 modified "2023-09-25" @default.
- W2021309719 title "Protein-protein Interfaces Integrated into Interaction Networks: Implications on Drug Design" @default.
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