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- W2021311574 abstract "The history of intervention trials of periconception folic acid with multivitamin and folic acid supplementation in women has shown a recent breakthrough in the primary prevention of structural birth defects, namely neural-tube defects and some other congenital abnormalities. Recently, some studies have demonstrated the efficacy of this new method in reducing congenital abnormalities with specific origin; for example, in the offspring of diabetic and epileptic mothers, and in pregnancy with high fever. The benefits and drawbacks of four possible uses of periconception folate/folic acid and multivitamin supplementation are discussed: we believe there has been a missed opportunity to implement this preventive approach in medical practice. The four methods are as follows: (i) dietary intake of folate and other vitamins, (ii) periconception folic acid/multivitamin supplementation, (iii) food fortification with folic acid, and (iv) the combination of oral contraceptives with 6S-5-methytetrahydrofolate (‘folate’)." @default.
- W2021311574 created "2016-06-24" @default.
- W2021311574 creator A5064642572 @default.
- W2021311574 creator A5064972922 @default.
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- W2021311574 date "2011-07-28" @default.
- W2021311574 modified "2023-10-16" @default.
- W2021311574 title "Primary prevention of neural-tube defects and some other congenital abnormalities by folic acid and multivitamins: history, missed opportunity and tasks" @default.
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- W2021311574 doi "https://doi.org/10.1177/2042098611411358" @default.
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