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- W2021330261 abstract "Mycobacterium tuberculosis modulates its virulence to cause persistent but often subclinical infection. This strategy is regulated in part by a feedback loop that controls the secretion of a small subset of bacterial proteins. The human pathogen Mycobacterium tuberculosis uses a protein secretion system called ESX-1 to export virulence factors that neutralize host defences. ESX-1 is known to be critical for virulence in the early stages of infection, but little is known about how it is regulated. Now work in a mouse model of tuberculosis shows that M. tuberculosis exports its own activator, a DNA-binding transcription factor termed EspR, which acts as a positive regulator of ESX-1. Since some of the proteins secreted by ESX-1 are major antigens being used in current clinical vaccine trials, this paper has potential implications for vaccine development." @default.
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- W2021330261 date "2008-08-06" @default.
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- W2021330261 title "Shrewd survival strategy" @default.
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- W2021330261 doi "https://doi.org/10.1038/454702a" @default.
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