Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021330306> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2021330306 endingPage "413" @default.
- W2021330306 startingPage "408" @default.
- W2021330306 abstract "ABSTRACT Background Various types of UVB radiation source (290–320 nm) are used in treating psoriasis and their therapeutic mechanism has been attributed to immunosuppressive properties. Recently, a new UVB source generated by a 308‐nm excimer laser has been introduced for the treatment of psoriasis. Objective In this study we investigated the immunohistochemical evaluation of T cells and the expression of various apoptosis‐related molecules in the psoriatic hyperproliferative skin before and after treatment with 308‐nm monochromatic excimer light (MEL). Methods Ten patients (three women and seven men), ranging in age from 29 to 79 years, affected by plaque‐type psoriasis vulgaris, were treated with MEL. Biopsies from psoriatic lesions of MEL‐treated sites were taken before, 24 h and/or 48 h after the first irradiation and analysed by the immunophosphatase alkaline technique (APAAP). Results MEL treatment was found to cause a significant decrease in the rate of proliferation of keratinocytes and a relevant depletion of T cells in all psoriatic lesions, 48 h after the first irradiation: 308 nm light eliminated T cells from the psoriatic epidermis and also from the dermis, highlighting the ability of this UVB source to penetrate the skin compared with normal UVB and establish direct cytotoxic action on T cells infiltrating skin lesions. Rapid clearing of psoriatic lesions involves potential molecular targets of UVB in T cells including p53, which is upregulated after direct irradiation with 308‐nm UVB. Moreover, Bcl‐2 expression in healing psoriasis epidermis after MEL treatment is significantly decreased compared with untreated skin and the TUNEL (TdT‐mediated dUTP‐biotin nick end labelling) technique revealed the presence of relevant apoptotic keratinocytes in the irradiated epidermis. Conclusions These results indicate that psoriatic skin after monochromatic excimer light therapy is associated with significant T‐cell depletion and alterations of apoptosis‐related molecules accompanied by a decreased proliferation index and clinical remission." @default.
- W2021330306 created "2016-06-24" @default.
- W2021330306 creator A5010258552 @default.
- W2021330306 creator A5039983462 @default.
- W2021330306 creator A5042226057 @default.
- W2021330306 creator A5069608830 @default.
- W2021330306 creator A5071205815 @default.
- W2021330306 creator A5088506261 @default.
- W2021330306 date "2003-06-27" @default.
- W2021330306 modified "2023-10-14" @default.
- W2021330306 title "Monochromatic excimer light (308 nm): an immunohistochemical study of cutaneous T cells and apoptosis-related molecules in psoriasis" @default.
- W2021330306 cites W1965621911 @default.
- W2021330306 cites W1970629830 @default.
- W2021330306 cites W1984988673 @default.
- W2021330306 cites W2007766576 @default.
- W2021330306 cites W2011018427 @default.
- W2021330306 cites W2013138674 @default.
- W2021330306 cites W2023561417 @default.
- W2021330306 cites W2048966567 @default.
- W2021330306 cites W2051866603 @default.
- W2021330306 cites W2117646004 @default.
- W2021330306 cites W2121580975 @default.
- W2021330306 cites W2121698961 @default.
- W2021330306 cites W2135967204 @default.
- W2021330306 cites W2136698338 @default.
- W2021330306 cites W2151261149 @default.
- W2021330306 cites W2314557249 @default.
- W2021330306 doi "https://doi.org/10.1046/j.1468-3083.2003.00758.x" @default.
- W2021330306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12834450" @default.
- W2021330306 hasPublicationYear "2003" @default.
- W2021330306 type Work @default.
- W2021330306 sameAs 2021330306 @default.
- W2021330306 citedByCount "88" @default.
- W2021330306 countsByYear W20213303062012 @default.
- W2021330306 countsByYear W20213303062013 @default.
- W2021330306 countsByYear W20213303062014 @default.
- W2021330306 countsByYear W20213303062015 @default.
- W2021330306 countsByYear W20213303062016 @default.
- W2021330306 countsByYear W20213303062017 @default.
- W2021330306 countsByYear W20213303062018 @default.
- W2021330306 countsByYear W20213303062019 @default.
- W2021330306 countsByYear W20213303062020 @default.
- W2021330306 countsByYear W20213303062021 @default.
- W2021330306 countsByYear W20213303062022 @default.
- W2021330306 crossrefType "journal-article" @default.
- W2021330306 hasAuthorship W2021330306A5010258552 @default.
- W2021330306 hasAuthorship W2021330306A5039983462 @default.
- W2021330306 hasAuthorship W2021330306A5042226057 @default.
- W2021330306 hasAuthorship W2021330306A5069608830 @default.
- W2021330306 hasAuthorship W2021330306A5071205815 @default.
- W2021330306 hasAuthorship W2021330306A5088506261 @default.
- W2021330306 hasConcept C105702510 @default.
- W2021330306 hasConcept C142724271 @default.
- W2021330306 hasConcept C16005928 @default.
- W2021330306 hasConcept C185592680 @default.
- W2021330306 hasConcept C190283241 @default.
- W2021330306 hasConcept C204232928 @default.
- W2021330306 hasConcept C2776458125 @default.
- W2021330306 hasConcept C2777624698 @default.
- W2021330306 hasConcept C2780564577 @default.
- W2021330306 hasConcept C502942594 @default.
- W2021330306 hasConcept C55493867 @default.
- W2021330306 hasConcept C71924100 @default.
- W2021330306 hasConceptScore W2021330306C105702510 @default.
- W2021330306 hasConceptScore W2021330306C142724271 @default.
- W2021330306 hasConceptScore W2021330306C16005928 @default.
- W2021330306 hasConceptScore W2021330306C185592680 @default.
- W2021330306 hasConceptScore W2021330306C190283241 @default.
- W2021330306 hasConceptScore W2021330306C204232928 @default.
- W2021330306 hasConceptScore W2021330306C2776458125 @default.
- W2021330306 hasConceptScore W2021330306C2777624698 @default.
- W2021330306 hasConceptScore W2021330306C2780564577 @default.
- W2021330306 hasConceptScore W2021330306C502942594 @default.
- W2021330306 hasConceptScore W2021330306C55493867 @default.
- W2021330306 hasConceptScore W2021330306C71924100 @default.
- W2021330306 hasIssue "4" @default.
- W2021330306 hasLocation W20213303061 @default.
- W2021330306 hasLocation W20213303062 @default.
- W2021330306 hasOpenAccess W2021330306 @default.
- W2021330306 hasPrimaryLocation W20213303061 @default.
- W2021330306 hasRelatedWork W1838021531 @default.
- W2021330306 hasRelatedWork W1995183519 @default.
- W2021330306 hasRelatedWork W1998984032 @default.
- W2021330306 hasRelatedWork W2101669640 @default.
- W2021330306 hasRelatedWork W2333032042 @default.
- W2021330306 hasRelatedWork W2397084142 @default.
- W2021330306 hasRelatedWork W2607000393 @default.
- W2021330306 hasRelatedWork W3139074489 @default.
- W2021330306 hasRelatedWork W4241775643 @default.
- W2021330306 hasRelatedWork W80417830 @default.
- W2021330306 hasVolume "17" @default.
- W2021330306 isParatext "false" @default.
- W2021330306 isRetracted "false" @default.
- W2021330306 magId "2021330306" @default.
- W2021330306 workType "article" @default.