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• W2021332892 abstract "A potentially lethal form of DNA/RNA modification, a cleavage complex, occurs when a nucleic acid-processing enzyme that acts via a transient covalent intermediate becomes trapped at its site of action. A number of overlapping pathways act to repair these lesions and many of the enzymes involved are those that catalyze recombinational-repair processes. A protein, Tdp1, has been identified that reverses cleavage-complex formation by specifically hydrolyzing a tyrosyl-DNA phosphodiester bond. The study of these pathways is both interesting and pertinent as they modulate the effectiveness of many antitumor/antibacterial drugs that act by stabilizing cleavage-complexes in vivo." @default.
• W2021332892 created "2016-06-24" @default.
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• W2021332892 creator A5028953694 @default.
• W2021332892 date "2004-02-01" @default.
• W2021332892 modified "2023-09-24" @default.
• W2021332892 title "Repair of DNA Covalently Linked to Protein" @default.
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• W2021332892 doi "https://doi.org/10.1016/s1097-2765(04)00056-5" @default.
• W2021332892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14967139" @default.
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