Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021347470> ?p ?o ?g. }
- W2021347470 endingPage "2229" @default.
- W2021347470 startingPage "2223" @default.
- W2021347470 abstract "Drug delivery to solid tumours remains a challenge because both tumour physiology and drug solubility are unfavourable. Engineered materials can provide the basis for drug reformulation, incorporating active compounds and modulating their pharmacokinetic and biodistribution behaviour. To this end, we encapsulated docetaxel, a poorly soluble taxane drug, in a self-assembled polymeric nanoparticle micelle of poly(2-methyl-2-carboxytrimethylene carbonate-co-d,l-lactide)-graft-poly(ethylene glycol) (poly(TMCC-co-LA)-g-PEG). This formulation was compared with its conventional ethanolic polysorbate 80 formulation in terms of plasma circulation and biodistribution in an orthotopic mouse model of breast cancer. Notably, the polymeric nanoparticle formulation achieved greater tumour retention, resulting in prolonged exposure of cancer cells to the active drug. This behaviour was unique to the tumour tissue. The active drug was eliminated at equal or greater rates in all other tissues assayed when delivered in the polymeric nanoparticles vs. the free drug formulation. Thus, these polymeric nanoparticles are promising vehicles for solid tumour drug delivery applications, offering greater tumour exposure while eliminating the need for toxic solvents and surfactants in the dosing formulation." @default.
- W2021347470 created "2016-06-24" @default.
- W2021347470 creator A5035216749 @default.
- W2021347470 creator A5045900479 @default.
- W2021347470 creator A5058799813 @default.
- W2021347470 creator A5065274106 @default.
- W2021347470 date "2012-03-01" @default.
- W2021347470 modified "2023-10-12" @default.
- W2021347470 title "Amphiphilic micelles of poly(2-methyl-2-carboxytrimethylene carbonate-co- -lactide)-graft-poly(ethylene glycol) for anti-cancer drug delivery to solid tumours" @default.
- W2021347470 cites W1965910946 @default.
- W2021347470 cites W1971421796 @default.
- W2021347470 cites W1976470852 @default.
- W2021347470 cites W1980103804 @default.
- W2021347470 cites W1983757740 @default.
- W2021347470 cites W1985241728 @default.
- W2021347470 cites W1987942958 @default.
- W2021347470 cites W2003474213 @default.
- W2021347470 cites W2013871471 @default.
- W2021347470 cites W2025628768 @default.
- W2021347470 cites W2029389980 @default.
- W2021347470 cites W2029749273 @default.
- W2021347470 cites W2032993907 @default.
- W2021347470 cites W2034365190 @default.
- W2021347470 cites W2043461452 @default.
- W2021347470 cites W2046926512 @default.
- W2021347470 cites W2051309616 @default.
- W2021347470 cites W2053276138 @default.
- W2021347470 cites W2055943659 @default.
- W2021347470 cites W2077318780 @default.
- W2021347470 cites W2079142824 @default.
- W2021347470 cites W2081729494 @default.
- W2021347470 cites W2084708671 @default.
- W2021347470 cites W2092581300 @default.
- W2021347470 cites W2096183208 @default.
- W2021347470 cites W2104558356 @default.
- W2021347470 cites W2107066718 @default.
- W2021347470 cites W2111362247 @default.
- W2021347470 cites W2116164394 @default.
- W2021347470 cites W2126754043 @default.
- W2021347470 cites W2130349349 @default.
- W2021347470 cites W2134348537 @default.
- W2021347470 cites W2136447069 @default.
- W2021347470 cites W2139687881 @default.
- W2021347470 cites W2144714372 @default.
- W2021347470 cites W2145502867 @default.
- W2021347470 cites W2147816095 @default.
- W2021347470 cites W2163887121 @default.
- W2021347470 cites W2169388316 @default.
- W2021347470 cites W2171227711 @default.
- W2021347470 doi "https://doi.org/10.1016/j.biomaterials.2011.11.072" @default.
- W2021347470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22182751" @default.
- W2021347470 hasPublicationYear "2012" @default.
- W2021347470 type Work @default.
- W2021347470 sameAs 2021347470 @default.
- W2021347470 citedByCount "37" @default.
- W2021347470 countsByYear W20213474702012 @default.
- W2021347470 countsByYear W20213474702013 @default.
- W2021347470 countsByYear W20213474702014 @default.
- W2021347470 countsByYear W20213474702015 @default.
- W2021347470 countsByYear W20213474702017 @default.
- W2021347470 countsByYear W20213474702018 @default.
- W2021347470 countsByYear W20213474702019 @default.
- W2021347470 countsByYear W20213474702020 @default.
- W2021347470 countsByYear W20213474702021 @default.
- W2021347470 countsByYear W20213474702022 @default.
- W2021347470 crossrefType "journal-article" @default.
- W2021347470 hasAuthorship W2021347470A5035216749 @default.
- W2021347470 hasAuthorship W2021347470A5045900479 @default.
- W2021347470 hasAuthorship W2021347470A5058799813 @default.
- W2021347470 hasAuthorship W2021347470A5065274106 @default.
- W2021347470 hasConcept C10138342 @default.
- W2021347470 hasConcept C11268172 @default.
- W2021347470 hasConcept C112705442 @default.
- W2021347470 hasConcept C121608353 @default.
- W2021347470 hasConcept C126322002 @default.
- W2021347470 hasConcept C13245373 @default.
- W2021347470 hasConcept C155574463 @default.
- W2021347470 hasConcept C155672457 @default.
- W2021347470 hasConcept C15920480 @default.
- W2021347470 hasConcept C162324750 @default.
- W2021347470 hasConcept C171250308 @default.
- W2021347470 hasConcept C178790620 @default.
- W2021347470 hasConcept C184651966 @default.
- W2021347470 hasConcept C185592680 @default.
- W2021347470 hasConcept C192562407 @default.
- W2021347470 hasConcept C202751555 @default.
- W2021347470 hasConcept C2776743539 @default.
- W2021347470 hasConcept C2777292972 @default.
- W2021347470 hasConcept C2777516009 @default.
- W2021347470 hasConcept C2777807558 @default.
- W2021347470 hasConcept C2779820397 @default.
- W2021347470 hasConcept C2780035454 @default.
- W2021347470 hasConcept C521977710 @default.
- W2021347470 hasConcept C54400483 @default.
- W2021347470 hasConcept C55493867 @default.
- W2021347470 hasConcept C67407626 @default.
- W2021347470 hasConcept C71924100 @default.
- W2021347470 hasConcept C98274493 @default.