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• W2021351223 endingPage "1464" @default.
• W2021351223 startingPage "1453" @default.
• W2021351223 abstract "The rodent olfactory epithelium (OE) is a good model system for studying the principles of stem and progenitor cell biology, because of its capacity for continuous neurogenesis throughout life and relatively well-characterized neuronal lineage. The development of mouse OE is divided into two stages, early and established neurogenesis. In established neurogenesis, which starts at embryonic day (E) 12.5, sustentacular cells and olfactory receptor neurons (ORNs) are produced from apical and basal progenitors, respectively. We previously reported that <I>Six1<SUP>-/-</SUP></I> shows a lack of mature ORNs throughout development and disorganization of OE after E12.5. However, the molecular bases for these defects have not been addressed. Here, we show that <I>Six1</I> is expressed in both apical and basal progenitors. In <I>Six1<SUP>-/-</SUP></I> mice, apical proliferating cells were absent and no morphologically identifiable sustentacular cells were observed. Consistently, the expression of <I>Notch2</I> and <I>Jagged1</I> in the apical layer was absent in <I>Six1<SUP>-/-</SUP></I> mice. On the other hand, basal proliferating cells were observed in <I>Six1<SUP>-/-</SUP></I> animals, but the expression of <I>Ngn1, NeuroD, Notch1,</I> and <I>Jagged2 </I>in the basal layer was absent. The expression of <I>Mash1</I>, the determination gene for ORNs, and <I>Hes</I> genes was enhanced in <I>Six1<SUP>-/-</SUP></I> mice. The present findings suggest that <I>Six1</I> regulates production of functional apical and basal progenitors during OE development, through the regulation of various genes, such as neuronal basic helix-loop-helix (bHLH), neuronal repressor bHLH, and genes involved in the Notch signaling pathway." @default.
• W2021351223 created "2016-06-24" @default.
• W2021351223 creator A5018917055 @default.
• W2021351223 creator A5020779902 @default.
• W2021351223 creator A5066146281 @default.
• W2021351223 creator A5066213912 @default.
• W2021351223 date "2010-01-01" @default.
• W2021351223 modified "2023-10-16" @default.
• W2021351223 title "Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development" @default.
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• W2021351223 doi "https://doi.org/10.1387/ijdb.093041ki" @default.
• W2021351223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21302255" @default.
• W2021351223 hasPublicationYear "2010" @default.
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