Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021352519> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2021352519 endingPage "282" @default.
- W2021352519 startingPage "275" @default.
- W2021352519 abstract "The cytochrome P450-dependent mixed-function oxidases are the most important enzyme system in the oxidation of chemicals to their reactive intermediates which then interact with cellular components to provoke toxicity and carcinogenicity. These enzymes comprise a multifamily of proteins, two families of which, namely CYP1A and CYP2E, activate planar and small molecular weight compounds, respectively. A computer graphic procedure (COMPACT) has been developed which, based on the molecular shape and electronic structure of the chemical, determines whether the chemical will interact with these two particular cytochrome P450 families and thus be metabolized to toxic and carcinogenic intermediates. As the basal levels of these enzyme families are low, the ability of the chemical to induce them selectively, on repeated administration, is an important determinant of its carcinogenic potential. Inductive capability may be determined in short-term experiments (ENACT) utilizing a small number of animals. Thus the combination of COMPACT and ENACT provides a rapid and inexpensive means for the preliminary screening of chemicals, before the long term and expensive rodent lifetime bioassays are undertaken." @default.
- W2021352519 created "2016-06-24" @default.
- W2021352519 creator A5062478675 @default.
- W2021352519 creator A5069410146 @default.
- W2021352519 creator A5087281525 @default.
- W2021352519 date "1993-05-01" @default.
- W2021352519 modified "2023-09-23" @default.
- W2021352519 title "Computer modelling in predicting carcinogenicity" @default.
- W2021352519 doi "https://doi.org/10.1097/00008469-199305000-00015" @default.
- W2021352519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8490550" @default.
- W2021352519 hasPublicationYear "1993" @default.
- W2021352519 type Work @default.
- W2021352519 sameAs 2021352519 @default.
- W2021352519 citedByCount "12" @default.
- W2021352519 crossrefType "journal-article" @default.
- W2021352519 hasAuthorship W2021352519A5062478675 @default.
- W2021352519 hasAuthorship W2021352519A5069410146 @default.
- W2021352519 hasAuthorship W2021352519A5087281525 @default.
- W2021352519 hasConcept C114246631 @default.
- W2021352519 hasConcept C14036430 @default.
- W2021352519 hasConcept C178790620 @default.
- W2021352519 hasConcept C181199279 @default.
- W2021352519 hasConcept C185592680 @default.
- W2021352519 hasConcept C29730261 @default.
- W2021352519 hasConcept C33070731 @default.
- W2021352519 hasConcept C526171541 @default.
- W2021352519 hasConcept C54355233 @default.
- W2021352519 hasConcept C55493867 @default.
- W2021352519 hasConcept C70721500 @default.
- W2021352519 hasConcept C86803240 @default.
- W2021352519 hasConceptScore W2021352519C114246631 @default.
- W2021352519 hasConceptScore W2021352519C14036430 @default.
- W2021352519 hasConceptScore W2021352519C178790620 @default.
- W2021352519 hasConceptScore W2021352519C181199279 @default.
- W2021352519 hasConceptScore W2021352519C185592680 @default.
- W2021352519 hasConceptScore W2021352519C29730261 @default.
- W2021352519 hasConceptScore W2021352519C33070731 @default.
- W2021352519 hasConceptScore W2021352519C526171541 @default.
- W2021352519 hasConceptScore W2021352519C54355233 @default.
- W2021352519 hasConceptScore W2021352519C55493867 @default.
- W2021352519 hasConceptScore W2021352519C70721500 @default.
- W2021352519 hasConceptScore W2021352519C86803240 @default.
- W2021352519 hasIssue "3" @default.
- W2021352519 hasLocation W20213525191 @default.
- W2021352519 hasLocation W20213525192 @default.
- W2021352519 hasOpenAccess W2021352519 @default.
- W2021352519 hasPrimaryLocation W20213525191 @default.
- W2021352519 hasRelatedWork W1993084845 @default.
- W2021352519 hasRelatedWork W1994136014 @default.
- W2021352519 hasRelatedWork W2004337431 @default.
- W2021352519 hasRelatedWork W2012833172 @default.
- W2021352519 hasRelatedWork W2016824196 @default.
- W2021352519 hasRelatedWork W2035768922 @default.
- W2021352519 hasRelatedWork W2054169229 @default.
- W2021352519 hasRelatedWork W2084571137 @default.
- W2021352519 hasRelatedWork W2158263952 @default.
- W2021352519 hasRelatedWork W2476584033 @default.
- W2021352519 hasVolume "2" @default.
- W2021352519 isParatext "false" @default.
- W2021352519 isRetracted "false" @default.
- W2021352519 magId "2021352519" @default.
- W2021352519 workType "article" @default.