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• W2021358082 startingPage "1861" @default.
• W2021358082 abstract "The human ADAMTS (a disintegrin and metalloproteinase with thrombospondin-like motifs) family of 19 secreted, multidomain proteolytic enzymes is involved in a wide range of biological processes including ECM assembly and degradation, hemostasis, organogenesis and the regulation of angiogenesis. Defects in certain family members give rise to inherited human genetic diseases, while aberrant expression of other ADAMTSs has been linked to the pathogenesis of arthritis and cancer. Several ADAMTSs act as tumor or metastasis suppressors whose functions are lost either by mutation or epigenetic silencing during tumor progression. This review looks in depth at the involvement of ADAMTSs as positive and negative mediators in cancer growth and spread." @default.
• W2021358082 created "2016-06-24" @default.
• W2021358082 creator A5071034728 @default.
• W2021358082 date "2011-01-01" @default.
• W2021358082 modified "2023-10-02" @default.
• W2021358082 title "The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis" @default.
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• W2021358082 doi "https://doi.org/10.2741/3827" @default.
• W2021358082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21196270" @default.
• W2021358082 hasPublicationYear "2011" @default.
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