Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021368845> ?p ?o ?g. }
- W2021368845 endingPage "1063" @default.
- W2021368845 startingPage "1045" @default.
- W2021368845 abstract "The defining property of an antibacterial agent is its ability to selectively interfere with bacterial growth and/or survival. Consequently, a considerable and crucial part of the preclinical evaluation of any novel antibacterial drug involves judging and characterising its effects on bacteria in vitro. These critical stages in drug development are sometimes made to appear somewhat trivial, sandwiched as they are between the highly demanding antibacterial discovery process and the formidable task of demonstrating safety and efficacy in vivo. However, careful biological evaluation in vitro is key to quantifying and understanding the basis of the antibacterial activity, providing preliminary indications and evaluations of therapeutic potential, assessing the likelihood for the development of bacterial resistance, guiding chemical refinement and assisting subsequent stages of the appraisal of any new antibacterial drug. This review covers concepts in, and strategies for, the in vitro microbiological and molecular evaluation of antibacterial drug candidates." @default.
- W2021368845 created "2016-06-24" @default.
- W2021368845 creator A5044018267 @default.
- W2021368845 creator A5061329142 @default.
- W2021368845 date "2004-08-01" @default.
- W2021368845 modified "2023-09-28" @default.
- W2021368845 title "Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques" @default.
- W2021368845 cites W1493155256 @default.
- W2021368845 cites W15601582 @default.
- W2021368845 cites W1582312374 @default.
- W2021368845 cites W1596190964 @default.
- W2021368845 cites W180569515 @default.
- W2021368845 cites W1952878961 @default.
- W2021368845 cites W1973879072 @default.
- W2021368845 cites W1975313075 @default.
- W2021368845 cites W1980881947 @default.
- W2021368845 cites W1982248439 @default.
- W2021368845 cites W1982950582 @default.
- W2021368845 cites W1986670886 @default.
- W2021368845 cites W1993430107 @default.
- W2021368845 cites W1996181473 @default.
- W2021368845 cites W1999180255 @default.
- W2021368845 cites W2002592515 @default.
- W2021368845 cites W2005294016 @default.
- W2021368845 cites W2008088946 @default.
- W2021368845 cites W2010796305 @default.
- W2021368845 cites W2024840104 @default.
- W2021368845 cites W2027916363 @default.
- W2021368845 cites W2029130563 @default.
- W2021368845 cites W2036838340 @default.
- W2021368845 cites W2040624414 @default.
- W2021368845 cites W2047161403 @default.
- W2021368845 cites W2048895938 @default.
- W2021368845 cites W2051361540 @default.
- W2021368845 cites W2051718455 @default.
- W2021368845 cites W2059327436 @default.
- W2021368845 cites W2059343446 @default.
- W2021368845 cites W2059897759 @default.
- W2021368845 cites W2062895955 @default.
- W2021368845 cites W2063563543 @default.
- W2021368845 cites W2065273069 @default.
- W2021368845 cites W2065583035 @default.
- W2021368845 cites W2066262757 @default.
- W2021368845 cites W2066353862 @default.
- W2021368845 cites W2072890859 @default.
- W2021368845 cites W2075197040 @default.
- W2021368845 cites W2076469336 @default.
- W2021368845 cites W2078624644 @default.
- W2021368845 cites W2084074709 @default.
- W2021368845 cites W2085165033 @default.
- W2021368845 cites W2093452340 @default.
- W2021368845 cites W2093634265 @default.
- W2021368845 cites W2093676491 @default.
- W2021368845 cites W2099734752 @default.
- W2021368845 cites W2100233093 @default.
- W2021368845 cites W2101820688 @default.
- W2021368845 cites W2104000223 @default.
- W2021368845 cites W2104986709 @default.
- W2021368845 cites W2107367202 @default.
- W2021368845 cites W2107698847 @default.
- W2021368845 cites W2108196738 @default.
- W2021368845 cites W2111151469 @default.
- W2021368845 cites W2115317294 @default.
- W2021368845 cites W2116078465 @default.
- W2021368845 cites W2117856769 @default.
- W2021368845 cites W2122465910 @default.
- W2021368845 cites W2127099118 @default.
- W2021368845 cites W2140357732 @default.
- W2021368845 cites W2145723496 @default.
- W2021368845 cites W2152238416 @default.
- W2021368845 cites W2156233344 @default.
- W2021368845 cites W2157638286 @default.
- W2021368845 cites W2158694008 @default.
- W2021368845 cites W2160824545 @default.
- W2021368845 cites W2164324013 @default.
- W2021368845 cites W2168759184 @default.
- W2021368845 cites W2169110988 @default.
- W2021368845 cites W2170343590 @default.
- W2021368845 cites W2170919860 @default.
- W2021368845 cites W2415951183 @default.
- W2021368845 cites W2435800666 @default.
- W2021368845 cites W2492507518 @default.
- W2021368845 cites W4240971294 @default.
- W2021368845 doi "https://doi.org/10.1517/13543784.13.8.1045" @default.
- W2021368845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15268641" @default.
- W2021368845 hasPublicationYear "2004" @default.
- W2021368845 type Work @default.
- W2021368845 sameAs 2021368845 @default.
- W2021368845 citedByCount "106" @default.
- W2021368845 countsByYear W20213688452012 @default.
- W2021368845 countsByYear W20213688452013 @default.
- W2021368845 countsByYear W20213688452014 @default.
- W2021368845 countsByYear W20213688452015 @default.
- W2021368845 countsByYear W20213688452016 @default.
- W2021368845 countsByYear W20213688452017 @default.
- W2021368845 countsByYear W20213688452018 @default.
- W2021368845 countsByYear W20213688452019 @default.
- W2021368845 countsByYear W20213688452020 @default.