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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021372044> ?p ?o ?g. }

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• W2021372044 abstract "We present here a structure-aided design of inhibitors targeting the active site as well as exosites of glutamate carboxypeptidase II (GCPII), a prostate cancer marker, preparing potent and selective inhibitors that are more than 1000-fold more active toward GCPII than its closest human homologue, glutamate carboxypeptidase III (GCPIII). Additionally, we demonstrate that the prepared inhibitor conjugate can be used for sensitive and selective imaging of GCPII in mammalian cells." @default.
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• W2021372044 date "2015-05-07" @default.
• W2021372044 modified "2023-10-03" @default.
• W2021372044 title "Design of Highly Potent Urea-Based, Exosite-Binding Inhibitors Selective for Glutamate Carboxypeptidase II" @default.
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• W2021372044 doi "https://doi.org/10.1021/acs.jmedchem.5b00278" @default.
• W2021372044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25923815" @default.
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