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• W2021378757 abstract "Abstract HIV-1 depends on host-cell resources for replication, access to which may be limited to a particular phase of the cell cycle. The HIV-encoded proteins Vpr (viral protein R) and Vif (viral infectivity factor) arrest cells in the G2 phase; however, alteration of other cell-cycle phases has not been reported. We show that Vif drives cells out of G1 and into the S phase. The effect of Vif on the G1-to-S transition is distinct from its effect on G2, because G2 arrest is Cullin5-dependent, whereas the G1-to-S progression is Cullin5-independent. Using mass spectrometry, we identified 2 novel cellular partners of Vif, Brd4 and Cdk9, both of which are known to regulate cell-cycle progression. We confirmed the interaction of Vif and Cdk9 by immunoprecipitation and Western blot, and showed that small interfering RNAs (siRNAs) specific for Cdk9 inhibit the Vif-mediated G1-to-S transition. These data suggest that Vif regulates early cell-cycle progression, with implications for infection and latency." @default.
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• W2021378757 date "2011-01-27" @default.
• W2021378757 modified "2023-09-27" @default.
• W2021378757 title "HIV-1 Vif promotes the G1- to S-phase cell-cycle transition" @default.
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• W2021378757 doi "https://doi.org/10.1182/blood-2010-06-289215" @default.
• W2021378757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3320848" @default.
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• W2021378757 hasPublicationYear "2011" @default.
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