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- W2021379779 abstract "An attempt has been made in this discussion to correlate the structure and function of carcinoid tumors with the clinical picture they produce. Consideration of the biochemistry and pharmacology of the tumor with respect to its humoral products, 5-hydroxytryptamine, kallikrein and histamine, allows some explanation of the varied occurrence of flushing, diarrhea and wheezing. In relation to the clinical syndrome emphasis has been placed upon the sequence of synthesis, storage release and metabolism of the tumor's humoral products as a basis for rational therapy and for diagnostic purposes. The pathology and clinical presentation of the endocardial lesions so frequently encountered in the carcinoid syndrome are also reviewed. The cause of these heart lesions is as yet unknown, but inferential reasoning leads to the conclusion that a humoral product of the tumor is responsible." @default.
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- W2021379779 date "1968-03-01" @default.
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- W2021379779 title "The carcinoid syndrome" @default.
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- W2021379779 doi "https://doi.org/10.1016/0002-9149(68)90142-2" @default.
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