FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021395821> ?p ?o ?g. }

• W2021395821 endingPage "172" @default.
• W2021395821 startingPage "163" @default.
• W2021395821 abstract "The enantiomeric bioinversion of ketoprofen (KP) enantiomers and their incorporation into triacylglycerols were investigated in the rat (1) in vitro, using liver homogenates, subcellular fractions, and hepatocytes, and (2) in vivo, in different tissue samples after oral administration of the radiolabelled compounds. In liver homogenates or subcellular fractions, the enantiomer (S)-ketoprofen (S-KP) was recovered unchanged, whereas (R)-ketoprofen (R-KP) was partially converted into its Coenzyme A (CoA) thioester and inverted to S-KP. Both processes occurred mainly in the mitochondrial fraction. This supports the mechanism of inversion via stereoselective formation of CoA thioesters of R-KP, already described for other non-steroidal anti-inflammatory drugs. Incorporation into triacylglycerols was detected after incubation with intact hepatocytes in the presence of added glycerol. The process was stereoselective for R-KP vs. S-KP (covalently bound radioactivity 26,742 ± 4,665 dpm/106 cells vs. 6,644 ± 3,179 dpm/106 cells, respectively). However, no incorporation was found in liver samples after oral administration of either R-KP or S-KP. On the contrary, in adipose tissue samples a significant and stereoselective formation of hybrid triacylglycerols was observed: 11,076 ± 2,790 dpm.g−1 for R-KP vs. 660 ± 268 dpm.g−1 for S-KP. The incorporated R/S ratio, higher in adipose tissue (R/S = 17) than in hepatocytes (R/S = 4), indicates that fat may be the main tissue store for the xenobiotic R-KP in rats. © 1996 Wiley-Liss, Inc." @default.
• W2021395821 created "2016-06-24" @default.
• W2021395821 creator A5014812896 @default.
• W2021395821 creator A5018673943 @default.
• W2021395821 creator A5019029446 @default.
• W2021395821 creator A5022591776 @default.
• W2021395821 creator A5027449465 @default.
• W2021395821 creator A5032621804 @default.
• W2021395821 creator A5032991851 @default.
• W2021395821 creator A5041690659 @default.
• W2021395821 creator A5046414392 @default.
• W2021395821 creator A5066136796 @default.
• W2021395821 creator A5076175137 @default.
• W2021395821 creator A5090441346 @default.
• W2021395821 creator A5046023449 @default.
• W2021395821 date "1996-01-01" @default.
• W2021395821 modified "2023-10-10" @default.
• W2021395821 title "Stereoselective metabolic pathways of ketoprofen in the rat: Incorporation into triacylglycerols and enantiomeric inversion" @default.
• W2021395821 cites W1516122519 @default.
• W2021395821 cites W1568402275 @default.
• W2021395821 cites W1963842437 @default.
• W2021395821 cites W1973991515 @default.
• W2021395821 cites W1974835739 @default.
• W2021395821 cites W1980902295 @default.
• W2021395821 cites W1981992413 @default.
• W2021395821 cites W2016729644 @default.
• W2021395821 cites W2020042552 @default.
• W2021395821 cites W2021545917 @default.
• W2021395821 cites W2036570914 @default.
• W2021395821 cites W2036945020 @default.
• W2021395821 cites W2037757244 @default.
• W2021395821 cites W2043038230 @default.
• W2021395821 cites W2047950825 @default.
• W2021395821 cites W2051018776 @default.
• W2021395821 cites W2060870413 @default.
• W2021395821 cites W2062116694 @default.
• W2021395821 cites W2063668251 @default.
• W2021395821 cites W2064442520 @default.
• W2021395821 cites W2065079376 @default.
• W2021395821 cites W2070072255 @default.
• W2021395821 cites W2072482644 @default.
• W2021395821 cites W2078751100 @default.
• W2021395821 cites W2082551941 @default.
• W2021395821 cites W2119926228 @default.
• W2021395821 cites W2311560103 @default.
• W2021395821 cites W2340763668 @default.
• W2021395821 cites W4293247451 @default.
• W2021395821 doi "https://doi.org/10.1002/(sici)1520-636x(1996)8:2<163::aid-chir1>3.0.co;2-k" @default.
• W2021395821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8857179" @default.
• W2021395821 hasPublicationYear "1996" @default.
• W2021395821 type Work @default.
• W2021395821 sameAs 2021395821 @default.
• W2021395821 citedByCount "22" @default.
• W2021395821 countsByYear W20213958212013 @default.
• W2021395821 countsByYear W20213958212015 @default.
• W2021395821 crossrefType "journal-article" @default.
• W2021395821 hasAuthorship W2021395821A5014812896 @default.
• W2021395821 hasAuthorship W2021395821A5018673943 @default.
• W2021395821 hasAuthorship W2021395821A5019029446 @default.
• W2021395821 hasAuthorship W2021395821A5022591776 @default.
• W2021395821 hasAuthorship W2021395821A5027449465 @default.
• W2021395821 hasAuthorship W2021395821A5032621804 @default.
• W2021395821 hasAuthorship W2021395821A5032991851 @default.
• W2021395821 hasAuthorship W2021395821A5041690659 @default.
• W2021395821 hasAuthorship W2021395821A5046023449 @default.
• W2021395821 hasAuthorship W2021395821A5046414392 @default.
• W2021395821 hasAuthorship W2021395821A5066136796 @default.
• W2021395821 hasAuthorship W2021395821A5076175137 @default.
• W2021395821 hasAuthorship W2021395821A5090441346 @default.
• W2021395821 hasConcept C150903083 @default.
• W2021395821 hasConcept C161790260 @default.
• W2021395821 hasConcept C171089720 @default.
• W2021395821 hasConcept C181647583 @default.
• W2021395821 hasConcept C185592680 @default.
• W2021395821 hasConcept C202751555 @default.
• W2021395821 hasConcept C207001950 @default.
• W2021395821 hasConcept C2779907587 @default.
• W2021395821 hasConcept C2780744026 @default.
• W2021395821 hasConcept C43617362 @default.
• W2021395821 hasConcept C486523 @default.
• W2021395821 hasConcept C55493867 @default.
• W2021395821 hasConcept C71240020 @default.
• W2021395821 hasConcept C86803240 @default.
• W2021395821 hasConcept C87644729 @default.
• W2021395821 hasConceptScore W2021395821C150903083 @default.
• W2021395821 hasConceptScore W2021395821C161790260 @default.
• W2021395821 hasConceptScore W2021395821C171089720 @default.
• W2021395821 hasConceptScore W2021395821C181647583 @default.
• W2021395821 hasConceptScore W2021395821C185592680 @default.
• W2021395821 hasConceptScore W2021395821C202751555 @default.
• W2021395821 hasConceptScore W2021395821C207001950 @default.
• W2021395821 hasConceptScore W2021395821C2779907587 @default.
• W2021395821 hasConceptScore W2021395821C2780744026 @default.
• W2021395821 hasConceptScore W2021395821C43617362 @default.
• W2021395821 hasConceptScore W2021395821C486523 @default.
• W2021395821 hasConceptScore W2021395821C55493867 @default.
• W2021395821 hasConceptScore W2021395821C71240020 @default.
• W2021395821 hasConceptScore W2021395821C86803240 @default.

• next