FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021402014> ?p ?o ?g. }

• W2021402014 endingPage "368" @default.
• W2021402014 startingPage "363" @default.
• W2021402014 abstract "Reactive oxygen species (ROS) such as superoxide anion (O2-*) and hydrogen peroxide (H2O2) can be produced by vascular endothelium and smooth muscle cells under diverse physiological and pathophysiological situations. These species are known to exert various deleterious effects by which they might induce changes in vascular reactivity. The aim of the present study was to evaluate the evolution of vascular susceptibility to H2O2 during aging in rats. Catalase activity was assessed in aortas from young adult (4 months) and aged (24 months) Wistar rats. In parallel experiments, isolated rings from both age groups were exposed to increasing doses of H2O2 (0, 0.1, 1, 5, or 10 mM) for 20 min and the residual vascular response to phenylephrine (PE = 10(-6) M) and acetylcholine (ACh = 10(-6) M) was evaluated. Our results indicate that aging increases aortic catalase activity (4 months: 0.20 +/- 0.02 IU/mg prot versus 24 months: 0.46 +/- 0.06 IU/mg prot, p < 0.001) while it exacerbates vascular sensitivity to H2O2. These results suggest that the observed increased H2O2-induced alterations of vascular reactivity during aging in rats might be due to increased sensitivity of the vasculature to ROS rather than to a decrease in the defense systems against these species." @default.
• W2021402014 created "2016-06-24" @default.
• W2021402014 creator A5008863721 @default.
• W2021402014 creator A5031198626 @default.
• W2021402014 creator A5034394564 @default.
• W2021402014 creator A5058862343 @default.
• W2021402014 creator A5073657475 @default.
• W2021402014 date "2000-06-01" @default.
• W2021402014 modified "2023-10-12" @default.
• W2021402014 title "Aging Exacerbates Hydrogen Peroxide-Induced Alteration of Vascular Reactivity in Rats" @default.
• W2021402014 cites W1775749144 @default.
• W2021402014 cites W1923535459 @default.
• W2021402014 cites W1974817453 @default.
• W2021402014 cites W1986473837 @default.
• W2021402014 cites W2003471941 @default.
• W2021402014 cites W2020263041 @default.
• W2021402014 cites W2026610291 @default.
• W2021402014 cites W2033678519 @default.
• W2021402014 cites W2033773063 @default.
• W2021402014 cites W2048732733 @default.
• W2021402014 cites W2051289202 @default.
• W2021402014 cites W2053933873 @default.
• W2021402014 cites W2059503466 @default.
• W2021402014 cites W2078348450 @default.
• W2021402014 cites W2160099189 @default.
• W2021402014 cites W2166540438 @default.
• W2021402014 cites W2170198401 @default.
• W2021402014 cites W2211078205 @default.
• W2021402014 cites W2259128162 @default.
• W2021402014 doi "https://doi.org/10.1089/ars.2000.2.2-363" @default.
• W2021402014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11229540" @default.
• W2021402014 hasPublicationYear "2000" @default.
• W2021402014 type Work @default.
• W2021402014 sameAs 2021402014 @default.
• W2021402014 citedByCount "14" @default.
• W2021402014 countsByYear W20214020142012 @default.
• W2021402014 countsByYear W20214020142013 @default.
• W2021402014 countsByYear W20214020142014 @default.
• W2021402014 countsByYear W20214020142015 @default.
• W2021402014 countsByYear W20214020142016 @default.
• W2021402014 countsByYear W20214020142021 @default.
• W2021402014 crossrefType "journal-article" @default.
• W2021402014 hasAuthorship W2021402014A5008863721 @default.
• W2021402014 hasAuthorship W2021402014A5031198626 @default.
• W2021402014 hasAuthorship W2021402014A5034394564 @default.
• W2021402014 hasAuthorship W2021402014A5058862343 @default.
• W2021402014 hasAuthorship W2021402014A5073657475 @default.
• W2021402014 hasConcept C10162356 @default.
• W2021402014 hasConcept C126322002 @default.
• W2021402014 hasConcept C134018914 @default.
• W2021402014 hasConcept C166397571 @default.
• W2021402014 hasConcept C181199279 @default.
• W2021402014 hasConcept C185592680 @default.
• W2021402014 hasConcept C2775838275 @default.
• W2021402014 hasConcept C2775910092 @default.
• W2021402014 hasConcept C2776151105 @default.
• W2021402014 hasConcept C2776992346 @default.
• W2021402014 hasConcept C2777663904 @default.
• W2021402014 hasConcept C2777952589 @default.
• W2021402014 hasConcept C2778979269 @default.
• W2021402014 hasConcept C2779395532 @default.
• W2021402014 hasConcept C2780795997 @default.
• W2021402014 hasConcept C2992686903 @default.
• W2021402014 hasConcept C48349386 @default.
• W2021402014 hasConcept C533411734 @default.
• W2021402014 hasConcept C55493867 @default.
• W2021402014 hasConcept C59822182 @default.
• W2021402014 hasConcept C71924100 @default.
• W2021402014 hasConcept C84393581 @default.
• W2021402014 hasConcept C86803240 @default.
• W2021402014 hasConceptScore W2021402014C10162356 @default.
• W2021402014 hasConceptScore W2021402014C126322002 @default.
• W2021402014 hasConceptScore W2021402014C134018914 @default.
• W2021402014 hasConceptScore W2021402014C166397571 @default.
• W2021402014 hasConceptScore W2021402014C181199279 @default.
• W2021402014 hasConceptScore W2021402014C185592680 @default.
• W2021402014 hasConceptScore W2021402014C2775838275 @default.
• W2021402014 hasConceptScore W2021402014C2775910092 @default.
• W2021402014 hasConceptScore W2021402014C2776151105 @default.
• W2021402014 hasConceptScore W2021402014C2776992346 @default.
• W2021402014 hasConceptScore W2021402014C2777663904 @default.
• W2021402014 hasConceptScore W2021402014C2777952589 @default.
• W2021402014 hasConceptScore W2021402014C2778979269 @default.
• W2021402014 hasConceptScore W2021402014C2779395532 @default.
• W2021402014 hasConceptScore W2021402014C2780795997 @default.
• W2021402014 hasConceptScore W2021402014C2992686903 @default.
• W2021402014 hasConceptScore W2021402014C48349386 @default.
• W2021402014 hasConceptScore W2021402014C533411734 @default.
• W2021402014 hasConceptScore W2021402014C55493867 @default.
• W2021402014 hasConceptScore W2021402014C59822182 @default.
• W2021402014 hasConceptScore W2021402014C71924100 @default.
• W2021402014 hasConceptScore W2021402014C84393581 @default.
• W2021402014 hasConceptScore W2021402014C86803240 @default.
• W2021402014 hasIssue "2" @default.
• W2021402014 hasLocation W20214020141 @default.
• W2021402014 hasLocation W20214020142 @default.
• W2021402014 hasLocation W20214020143 @default.
• W2021402014 hasOpenAccess W2021402014 @default.

• next