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• W2021409596 abstract "Nr4a1 and Nr4a2 are transcription factors and immediate early genes belonging to the nuclear receptor Nr4a family. In this study, we examine their role in long-term memory formation for object location and object recognition. Using siRNA to block expression of either Nr4a1 or Nr4a2, we found that Nr4a2 is necessary for both long-term memory for object location and object recognition. In contrast, Nr4a1 appears to be necessary only for object location. Indeed, their roles in these different types of long-term memory may be dependent on their expression in the brain, as NR4A2 was found to be expressed in hippocampal neurons (associated with object location memory) as well as in the insular and perirhinal cortex (associated with object recognition memory), whereas NR4A1 showed minimal neuronal expression in these cortical areas. These results begin to elucidate how NR4A1 and NR4A2 differentially contribute to object location versus object recognition memory." @default.
• W2021409596 created "2016-06-24" @default.
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• W2021409596 date "2012-11-16" @default.
• W2021409596 modified "2023-10-05" @default.
• W2021409596 title "Differential roles for <i>Nr4a1</i> and <i>Nr4a2</i> in object location vs. object recognition long-term memory" @default.
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• W2021409596 doi "https://doi.org/10.1101/lm.026385.112" @default.
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