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• W2021412899 endingPage "732" @default.
• W2021412899 startingPage "710" @default.
• W2021412899 abstract "Interneurons, which release the neurotransmitter γ-aminobutyric acid (GABA), are the major inhibitory cells of the central nervous system (CNS). Despite comprising only 20-30% of the cerebral cortical neuronal population, these cells play an essential and powerful role in modulating the electrical activity of the excitatory pyramidal cells onto which they synapse. Although interneurons are present in all regions of the mature telencephalon, during embryogenesis these cells are generated in specific compartments of the ventral (subpallial) telencephalon known as ganglionic eminences. To reach their final destinations in the mature brain, immature interneurons migrate from the ganglionic eminences to developing telencephalic structures that are both near and far from their site of origin. The specification and migration of these cells is a complex but precisely orchestrated process that is regulated by a combination of intrinsic and extrinsic signals. The final outcome of which is the wiring together of excitatory and inhibitory neurons that were born in separate regions of the developing telencephalon. Disruption of any aspect of this sequence of events during development, either from an environmental insult or due to genetic mutations, can have devastating consequences on normal brain function." @default.
• W2021412899 created "2016-06-24" @default.
• W2021412899 creator A5017337219 @default.
• W2021412899 creator A5027410544 @default.
• W2021412899 date "2011-07-09" @default.
• W2021412899 modified "2023-10-16" @default.
• W2021412899 title "Developmental mechanisms for the generation of telencephalic interneurons" @default.
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