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• W2021424333 startingPage "121" @default.
• W2021424333 abstract "Free radicals and oxidant gases, such as oxygen (O2) and nitrogen dioxide (NO2), are injurious to mammalian lung cells. One of the postulated mechanisms for the cellular injury associated with these gases and free radicals involves peroxidative cleavage of membrane lipids. We have hypothesized that oxidant-related alterations in membrane lipids may result in disordering of the plasma membrane lipid bilayer, leading to derangements in membrane-dependent functions. To test this hypothesis, we examined the effect of exposure to high partial pressures of O2 or NO2 on the physical state and function of pulmonary endothelial cell plasma membranes. Both hyperoxia (95% O2 at 1 ATA) and NO2 exposure (5 ppm) caused early and significant decreases in fluidity in the hydrophobic interior of the plasma membrane lipid bilayer and subsequent depressions in plasma membrane-dependent transport of 5-hydroxytryptamine. Lipid domains at the surface of pulmonary endothelial cell plasma membranes are more susceptible to NO2-induced injury than to hyperoxic injury. Alterations in the fluidity of these more superficial domains are associated with derangements in surface dependent functions, such as receptor-ligand interaction. These results support our hypothesis and advance our understanding of how the chemical events of free radical injury associated with high O2 and NO2 tensions are translated into functional manifestations of O2 and NO2-induced cellular injury." @default.
• W2021424333 created "2016-06-24" @default.
• W2021424333 creator A5040247825 @default.
• W2021424333 creator A5086158707 @default.
• W2021424333 date "1988-01-01" @default.
• W2021424333 modified "2023-09-23" @default.
• W2021424333 title "The effect of oxidant gases on membrane fluidity and function in pulmonary endothelial cells" @default.
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• W2021424333 doi "https://doi.org/10.1016/0891-5849(88)90072-x" @default.
• W2021424333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3278951" @default.
• W2021424333 hasPublicationYear "1988" @default.
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