FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021437128> ?p ?o ?g. }

• W2021437128 endingPage "n/a" @default.
• W2021437128 startingPage "n/a" @default.
• W2021437128 abstract "It has been reported that one of the serious adverse events after the treatment of oseltamivir phosphate (OP) for influenza patients is sudden death resulting from cardiorespiratory arrest. To investigate the aetiology of such an adverse consequence, we examined effects of OP (expressed as free base) on blood pressure and ventilation in anaesthetized rats with vagotomy. Intravenous OP (30–200 mg/kg) caused dose-dependent hypotension and bradycardia in spontaneously breathing animals. Concomitantly with changes in blood pressure, the tracheal airflow increased. The ventilatory rate hastened during the injection and then transiently slowed around 1 min. after the administration (transient hypopnea). Thereafter, it gradually returned to control. The hypopnea increased with increasing dose and ventilatory arrest occurred at 200 mg/kg. Intraduodenal OP (500–1000 mg/kg) provoked cardioventilatory arrest 72–218 min. after the injection. Oseltamivir carboxylate (100–200 mg/kg, i.v.), an active metabolite of OP, had no significant effect on ventilation and blood pressure. In artificially ventilated animals, intravenous OP caused slowing of the respiratory rate around 1 min. after the injection in a dose-dependent manner. This effect of OP waned in 5 min. after the administration. The amplitude of phrenic nerve discharge was not changed at lower doses (30–100 mg/kg). The phrenic nerve stopped to discharge immediately after higher doses (150–200 mg/kg). We demonstrated that OP causes central suppression of the respiratory function in rats and suggest a relationship between the OP-induced cardiorespiratory arrest and sudden death observed in influenza patients after taking OP." @default.
• W2021437128 created "2016-06-24" @default.
• W2021437128 creator A5007017957 @default.
• W2021437128 creator A5036697515 @default.
• W2021437128 creator A5064103518 @default.
• W2021437128 creator A5069047580 @default.
• W2021437128 creator A5069257391 @default.
• W2021437128 creator A5069419670 @default.
• W2021437128 creator A5076970365 @default.
• W2021437128 creator A5078797158 @default.
• W2021437128 creator A5079417918 @default.
• W2021437128 creator A5091092306 @default.
• W2021437128 date "2012-04-01" @default.
• W2021437128 modified "2023-09-24" @default.
• W2021437128 title "High Doses of Oseltamivir Phosphate Induce Acute Respiratory Arrest in Anaesthetized Rats" @default.
• W2021437128 cites W1512007375 @default.
• W2021437128 cites W172188350 @default.
• W2021437128 cites W1969698674 @default.
• W2021437128 cites W1973642476 @default.
• W2021437128 cites W1990495497 @default.
• W2021437128 cites W2000698357 @default.
• W2021437128 cites W2003124094 @default.
• W2021437128 cites W2004340453 @default.
• W2021437128 cites W2004671038 @default.
• W2021437128 cites W2007304817 @default.
• W2021437128 cites W2010028861 @default.
• W2021437128 cites W2034461950 @default.
• W2021437128 cites W2038870421 @default.
• W2021437128 cites W2042866285 @default.
• W2021437128 cites W2053388365 @default.
• W2021437128 cites W2054650621 @default.
• W2021437128 cites W2081460129 @default.
• W2021437128 cites W2085927124 @default.
• W2021437128 cites W2095246436 @default.
• W2021437128 cites W2125220257 @default.
• W2021437128 cites W2129482098 @default.
• W2021437128 cites W2139837686 @default.
• W2021437128 cites W2144163194 @default.
• W2021437128 cites W2147682506 @default.
• W2021437128 cites W2150047295 @default.
• W2021437128 cites W2163231573 @default.
• W2021437128 cites W4237806915 @default.
• W2021437128 cites W1987895052 @default.
• W2021437128 doi "https://doi.org/10.1111/j.1742-7843.2012.00889.x" @default.
• W2021437128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22524333" @default.
• W2021437128 hasPublicationYear "2012" @default.
• W2021437128 type Work @default.
• W2021437128 sameAs 2021437128 @default.
• W2021437128 citedByCount "3" @default.
• W2021437128 countsByYear W20214371282012 @default.
• W2021437128 countsByYear W20214371282014 @default.
• W2021437128 countsByYear W20214371282016 @default.
• W2021437128 crossrefType "journal-article" @default.
• W2021437128 hasAuthorship W2021437128A5007017957 @default.
• W2021437128 hasAuthorship W2021437128A5036697515 @default.
• W2021437128 hasAuthorship W2021437128A5064103518 @default.
• W2021437128 hasAuthorship W2021437128A5069047580 @default.
• W2021437128 hasAuthorship W2021437128A5069257391 @default.
• W2021437128 hasAuthorship W2021437128A5069419670 @default.
• W2021437128 hasAuthorship W2021437128A5076970365 @default.
• W2021437128 hasAuthorship W2021437128A5078797158 @default.
• W2021437128 hasAuthorship W2021437128A5079417918 @default.
• W2021437128 hasAuthorship W2021437128A5091092306 @default.
• W2021437128 hasConcept C126322002 @default.
• W2021437128 hasConcept C127413603 @default.
• W2021437128 hasConcept C200457457 @default.
• W2021437128 hasConcept C2777099253 @default.
• W2021437128 hasConcept C2777495988 @default.
• W2021437128 hasConcept C2777953023 @default.
• W2021437128 hasConcept C2778720886 @default.
• W2021437128 hasConcept C2780457178 @default.
• W2021437128 hasConcept C42219234 @default.
• W2021437128 hasConcept C534529494 @default.
• W2021437128 hasConcept C71924100 @default.
• W2021437128 hasConcept C78519656 @default.
• W2021437128 hasConcept C8213797 @default.
• W2021437128 hasConcept C84393581 @default.
• W2021437128 hasConceptScore W2021437128C126322002 @default.
• W2021437128 hasConceptScore W2021437128C127413603 @default.
• W2021437128 hasConceptScore W2021437128C200457457 @default.
• W2021437128 hasConceptScore W2021437128C2777099253 @default.
• W2021437128 hasConceptScore W2021437128C2777495988 @default.
• W2021437128 hasConceptScore W2021437128C2777953023 @default.
• W2021437128 hasConceptScore W2021437128C2778720886 @default.
• W2021437128 hasConceptScore W2021437128C2780457178 @default.
• W2021437128 hasConceptScore W2021437128C42219234 @default.
• W2021437128 hasConceptScore W2021437128C534529494 @default.
• W2021437128 hasConceptScore W2021437128C71924100 @default.
• W2021437128 hasConceptScore W2021437128C78519656 @default.
• W2021437128 hasConceptScore W2021437128C8213797 @default.
• W2021437128 hasConceptScore W2021437128C84393581 @default.
• W2021437128 hasLocation W20214371281 @default.
• W2021437128 hasLocation W20214371282 @default.
• W2021437128 hasOpenAccess W2021437128 @default.
• W2021437128 hasPrimaryLocation W20214371281 @default.
• W2021437128 hasRelatedWork W1993663790 @default.
• W2021437128 hasRelatedWork W1999651256 @default.
• W2021437128 hasRelatedWork W2013013378 @default.

• next