FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021446327> ?p ?o ?g. }

• W2021446327 endingPage "4668" @default.
• W2021446327 startingPage "4666" @default.
• W2021446327 abstract "Abstract Plasmacytoid dendritic cells (PDCs) are crucial effectors in innate immunity. In this study, we show that imatinib, a potent inhibitor of BCR/ABL tyrosine kinase activity, in the presence of Flt3-Ligand, could induce CD34+ progenitors from chronic myeloid leukemia (CML) to give rise in vitro to typical BDCA-2+ type I interferon-producing PDCs. The effect of imatinib on PDC generation was related to up-regulation of Flt3 on leukemic CD34+ progenitors. Moreover, patients with chronic myeloid leukemia (CML) who were in complete cytogenetic or molecular response after imatinib treatment restored their blood PDCs both quantitatively and functionally comparable to healthy donors, in contrast to patients not responding to imatinib, further confirming that disease response to imatinib is accompanied by restoration of PDC function in vivo. These findings provide evidence that response to imatinib is capable to restore some DC-related immune functions in CML that might be beneficial for long-term disease control. (Blood. 2004;103:4666-4668)" @default.
• W2021446327 created "2016-06-24" @default.
• W2021446327 creator A5020996390 @default.
• W2021446327 creator A5022161221 @default.
• W2021446327 creator A5028950361 @default.
• W2021446327 creator A5029679351 @default.
• W2021446327 creator A5037888163 @default.
• W2021446327 creator A5049246533 @default.
• W2021446327 creator A5053724616 @default.
• W2021446327 creator A5087936549 @default.
• W2021446327 creator A5088991230 @default.
• W2021446327 date "2004-06-15" @default.
• W2021446327 modified "2023-10-09" @default.
• W2021446327 title "Imatinib and plasmacytoid dendritic cell function in patients with chronic myeloid leukemia" @default.
• W2021446327 cites W120676909 @default.
• W2021446327 cites W12745932 @default.
• W2021446327 cites W1517310071 @default.
• W2021446327 cites W1707184873 @default.
• W2021446327 cites W1975463463 @default.
• W2021446327 cites W1977092622 @default.
• W2021446327 cites W2016656445 @default.
• W2021446327 cites W2018279800 @default.
• W2021446327 cites W2040396943 @default.
• W2021446327 cites W2041999190 @default.
• W2021446327 cites W2056461632 @default.
• W2021446327 cites W2077752679 @default.
• W2021446327 cites W2080801585 @default.
• W2021446327 cites W2101642059 @default.
• W2021446327 cites W2107265716 @default.
• W2021446327 cites W2113779347 @default.
• W2021446327 cites W2133350434 @default.
• W2021446327 cites W2155792963 @default.
• W2021446327 cites W2158913853 @default.
• W2021446327 cites W2161503027 @default.
• W2021446327 cites W2170933182 @default.
• W2021446327 cites W2320180589 @default.
• W2021446327 cites W2321136711 @default.
• W2021446327 cites W2329648702 @default.
• W2021446327 doi "https://doi.org/10.1182/blood-2003-09-3220" @default.
• W2021446327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14715630" @default.
• W2021446327 hasPublicationYear "2004" @default.
• W2021446327 type Work @default.
• W2021446327 sameAs 2021446327 @default.
• W2021446327 citedByCount "57" @default.
• W2021446327 countsByYear W20214463272012 @default.
• W2021446327 countsByYear W20214463272013 @default.
• W2021446327 countsByYear W20214463272015 @default.
• W2021446327 countsByYear W20214463272016 @default.
• W2021446327 countsByYear W20214463272017 @default.
• W2021446327 countsByYear W20214463272018 @default.
• W2021446327 countsByYear W20214463272019 @default.
• W2021446327 countsByYear W20214463272021 @default.
• W2021446327 countsByYear W20214463272023 @default.
• W2021446327 crossrefType "journal-article" @default.
• W2021446327 hasAuthorship W2021446327A5020996390 @default.
• W2021446327 hasAuthorship W2021446327A5022161221 @default.
• W2021446327 hasAuthorship W2021446327A5028950361 @default.
• W2021446327 hasAuthorship W2021446327A5029679351 @default.
• W2021446327 hasAuthorship W2021446327A5037888163 @default.
• W2021446327 hasAuthorship W2021446327A5049246533 @default.
• W2021446327 hasAuthorship W2021446327A5053724616 @default.
• W2021446327 hasAuthorship W2021446327A5087936549 @default.
• W2021446327 hasAuthorship W2021446327A5088991230 @default.
• W2021446327 hasBestOaLocation W20214463271 @default.
• W2021446327 hasConcept C109159458 @default.
• W2021446327 hasConcept C121608353 @default.
• W2021446327 hasConcept C126322002 @default.
• W2021446327 hasConcept C170493617 @default.
• W2021446327 hasConcept C201750760 @default.
• W2021446327 hasConcept C203014093 @default.
• W2021446327 hasConcept C2776051438 @default.
• W2021446327 hasConcept C2777583451 @default.
• W2021446327 hasConcept C2778170410 @default.
• W2021446327 hasConcept C2778461978 @default.
• W2021446327 hasConcept C2778729363 @default.
• W2021446327 hasConcept C2778820342 @default.
• W2021446327 hasConcept C2779282312 @default.
• W2021446327 hasConcept C2780007613 @default.
• W2021446327 hasConcept C28328180 @default.
• W2021446327 hasConcept C3019892230 @default.
• W2021446327 hasConcept C42362537 @default.
• W2021446327 hasConcept C502942594 @default.
• W2021446327 hasConcept C71924100 @default.
• W2021446327 hasConcept C86803240 @default.
• W2021446327 hasConcept C8891405 @default.
• W2021446327 hasConcept C95444343 @default.
• W2021446327 hasConceptScore W2021446327C109159458 @default.
• W2021446327 hasConceptScore W2021446327C121608353 @default.
• W2021446327 hasConceptScore W2021446327C126322002 @default.
• W2021446327 hasConceptScore W2021446327C170493617 @default.
• W2021446327 hasConceptScore W2021446327C201750760 @default.
• W2021446327 hasConceptScore W2021446327C203014093 @default.
• W2021446327 hasConceptScore W2021446327C2776051438 @default.
• W2021446327 hasConceptScore W2021446327C2777583451 @default.
• W2021446327 hasConceptScore W2021446327C2778170410 @default.
• W2021446327 hasConceptScore W2021446327C2778461978 @default.
• W2021446327 hasConceptScore W2021446327C2778729363 @default.
• W2021446327 hasConceptScore W2021446327C2778820342 @default.

• next